Antimicrobial biaryl compounds

Details Antimicrobial biaryl compounds Antimicrobial biaryl compounds

2005-02-01

2005-02-01

Coleman, Brenda (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S249000, C514S252200, C514S252130, C514S252160, C514S253040, C514S254100, C514S263230, C514S266400, C514S274000, C514S326000, C514S343000, C514S422000, C544S264000, C544S265000, C544S274000, C544S276000, C544S277000, C544S295000, C544S354000, C544S362000, C544S379000, C546S208000, C546S278400, C548S517000, C549S013000, C549S028000, C549S063000, C549S065000, C549S419000, C549S424000, C549S425000, C549S426000, C549S479000, C549S480000, C549S483000, C549S487000

Reexamination Certificate

active

06849660

ABSTRACT:
Provided are antibacterial compounds having Formula I:In such compositions, X is O or S; Y is CH2; n is0or1. One of R1and R1′is —C(O)NR5R5′, —C(O)—Q—NR5R5′, —CH2NR5R5′or —S(O)2NR5R5′and the other is H or R3. One of R2and R2′is —NHC(O)R6or —NHS(O)2R6and the other is H or R4. Q is an amino acid or peptide. R3is H, halogen, —NR5R5′or —NHC(O)R6; and R4is selected from the group consisting of H, halogen, hydroxyl, amino, carboxyl, alkyl, alkenyl and alkynyl. R5is selected from the group consisting of H, alkyl, alkenyl or alkynyl optionally substituted with halogen, OH, amino, amidinyl, guanidinyl, urea, alkyl, carboxyl, oxo, carboxamide; R5′is H or R5and R5′together form a 5-16 member heterocycle optionally substituted with halogen, OH, amino, alkyl, carboxyl, carbonyl or carboxamide. R6is selected from the group consisting of H; amino; alkyl, alkenyl or alkynyl, each optionally substituted with halogen, amino, amidinyl, guanidinyl, urea, carboxyl or carboxamide; a 5-16 member carbocycle or heterocycle; and a 5-16 member heterocycle-substituted alkyl or carbocycle-substituted alkyl, wherein said carbocycle and heterocycle are optionally substituted with halogen, OH, amino, alkyl, carboxyl, oxo or carboxamide.

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