Method for Raman chemical imaging of endogenous chemicals to...

Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation

Reexamination Certificate

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C600S407000, C600S473000, C600S477000, C600S310000, C600S318000, C356S301000, C356S303000, C606S002000, C606S003000, C606S004000, C606S010000

Reexamination Certificate

active

06965793

ABSTRACT:
Apparatus and methods for spatially resolved Raman detection of molecules indicative of the borders of lesions with normal tissue are disclosed. A region of biological tissue was illuminated with monochromatic light. A Raman shifted light signal is detected from endogenous molecules in the region, the molecules being spatially organized in a localized first area of the region. These molecules are indicative of a border between normal tissue and a lesion. The Raman shifted light signal is then spatially resolved in at least one direction.

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