Tetrahydropyran derivatives as neurokinin receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S382000, C514S383000, C514S384000, C514S459000, C514S460000, C546S207000, C549S416000, C549S419000, C548S252000, C548S263200, C548S268800

Reexamination Certificate

active

06906085

ABSTRACT:
The present invention relates compounds of the formula (I):wherein R1, R2, R3, R4, R5, R6, R7and R8represent a variety of substituents; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

REFERENCES:
patent: WO 0056727 (2000-09-01), None
Chemical Abstracts Service, vol. 70, No. 25, Jun. 23, 1969, Y. Kai, M. Shimizu: “Phenolic constituents fromCryptomeria joaponicawood, V. Structure of hydroxysugiresinol” vol. 14, No. 8, 1986, pp. 430-433.

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