Translation enhancer element of the human amyloid precursor...

Details Translation enhancer element of the human amyloid precursor... Translation enhancer element of the human amyloid precursor...

2005-02-01

2005-02-01

Turner, Sharon L. (Department: 1647)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C436S504000, C536S023100, C536S024100

Reexamination Certificate

active

06849405

ABSTRACT:
The present invention is directed to a DNA element that enhances the translation of the human amyloid precursor protein (APP) gene. The enhancer may be incorporated into expression vectors to enhance recombinant protein production. In addition, the invention is directed to an assay that utilizes vectors containing the translation enhancer element for the purpose of identifying agents that modulate the expression of the human amyloid precursor protein. These agents will ultimately be used to suppress APP expression in patients with Alzheimer's disease.

REFERENCES:
patent: 6310197 (2001-10-01), Rogers
Goldgarber et al, PNAS, 86:7606-10, Oct., 1989.*
Mita et al., Nucleic Acids Res., 16(19):9351, 1988.

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