Medical compositions for intravesical treatment of bladder...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S053000, C514S058000, C514S772000, C514S777000, C514S908000, C514S952000, C514S970000, C424S489000, C424S490000, C424S493000

Reexamination Certificate

active

06894071

ABSTRACT:
Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9 and a formulation vehicle. The formulation vehicle improves the solubility and stability of EO9. Additionally, the coating compositions can include coating agents that provide better adhesion of the coating composition to the bladder wall during intravesical delivery of the coating composition.

REFERENCES:
patent: 4871542 (1989-10-01), Vilhardt
patent: 5292516 (1994-03-01), Viegas et al.
patent: 5346703 (1994-09-01), Viegas et al.
patent: 5405622 (1995-04-01), Vernice et al.
patent: 5744166 (1998-04-01), Illum
patent: 5749845 (1998-05-01), Hildebrand et al.
patent: 5814330 (1998-09-01), Putteman et al.
patent: 5843156 (1998-12-01), Slepian et al.
patent: 5942209 (1999-08-01), Leavitt et al.
patent: 5993846 (1999-11-01), Friedman et al.
patent: 6005020 (1999-12-01), Loomis
patent: 6039967 (2000-03-01), Ottoboni et al.
patent: 6087396 (2000-07-01), Roberts
patent: 6123965 (2000-09-01), Jacob et al.
patent: 6156348 (2000-12-01), Santos et al.
patent: 6171610 (2001-01-01), Vacanti et al.
patent: 6207180 (2001-03-01), Ottoboni et al.
patent: 0 331 635 (1989-09-01), None
patent: 0 338 679 (1989-10-01), None
patent: 0393575 (1990-10-01), None
patent: 0 426 463 (1991-05-01), None
patent: 0 501 523 (1992-09-01), None
patent: 0 642 797 (1995-03-01), None
patent: 354151134 (1979-11-01), None
patent: 360163821 (1985-08-01), None
patent: 361189215 (1986-08-01), None
patent: 407215843 (1995-08-01), None
patent: 02000256182 (2000-09-01), None
patent: 02001010951 (2001-01-01), None
patent: 8706227 (1987-10-01), None
patent: WO 9726864 (1997-07-01), None
patent: 9912548 (1999-03-01), None
patent: WO 9965463 (1999-12-01), None
patent: WO 0033816 (2000-06-01), None
Chemical Abstracts 120:62141 (1994).*
Chemical Abstracts 122:17023 (1995).*
Choudry et al.; A Novel Strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) Mediated Therapy of Bladder Cancer Based on the Pharmacological Properties of EO9; British Journal of Cancer; Oct. 19, 2001; vol. 85, No. 9; pp. 1137-1146.
Schellens et al.; Phase I and pharmacologic study of the novel indoloquinone bioreductive alkylating cytotoxic drug EO9; Journal of the National Cancer Institute; vol. 86, No. 12, pp. 906-912.
Robertson et al.; Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia; European Journal of Cancer; vol. 30A, No. 7, 1994, pp. 1013-1019.
Dong Li et al; Distribution of DT-diaphorase and cytochrome P450 reductase in human bladder tissues and tumors; Proceedings of the American Association for Cancer Research Annual; vol. 42, Mar. 2001, p. 648.
Kantoff et al; Bladder Cancer; Neoplasms of the Genitourinary Tract; Chapter 107; p 1543-1558.
Cummings et al.; Pharmacological and biochemical Determinants of the Antitumour Activity of the Indoloquinone EO9; Biochemical Pharmacology, vol. 55, No. 3, Feb 1, 1998, pp. 253-260.
Nicolaus; Symbiotic approach to Drug Design; Decision Making in Drug Research, 1983, pp. 173-186.

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