Process for the preparation of amorphous atorvastatin

Details Process for the preparation of amorphous atorvastatin Process for the preparation of amorphous atorvastatin

2005-05-10

2005-05-10

Desai, Rita (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06891047

ABSTRACT:
Atorvastatin, the substance known by the chemical name [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt, is readily available in one of its crystalline forms as it is known from the prior art. The present invention relates to a novel process for preparing atorvastatin in an amorphous form by precipitating the atorvastatin using a solvent of a second type from a solution of atorvastatin which is provided with a solvent of a first type. This process is useful for the conversion of atorvastatin in a crystalline form into atorvastatin in an amorphous form.

REFERENCES:
patent: 5273995 (1993-12-01), Roth
patent: 5385929 (1995-01-01), Bjorge et al.
patent: 6528660 (2003-03-01), Kumar et al.
patent: 6613916 (2003-09-01), Pflaum
patent: WO 9703958 (1996-07-01), None
patent: WO 9703959 (1996-07-01), None
patent: WO 9703960 (1996-07-01), None
patent: WO 0071116 (2000-11-01), None
Baumann et al, The Convergent Synthesis of CI-981, an Optically Active, Highly Potent, Tissue Selective Inhibitor of HMG-CoA Reductase, Apr. 21, 1992.
Database Chemabs 1998.

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