Spiro-cyclic β-amino acid derivatives as inhibitors of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S438000, C514S462000, C549S030000, C549S200000, C549S300000, C549S322000, C549S337000, C549S341000, C548S407000

Reexamination Certificate

active

06962938

ABSTRACT:
The present application describes novel spiro-cyclic β-amino acid derivatives of formula I:or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), and/or aggrecanase inhibitors.

REFERENCES:
patent: 4261990 (1981-04-01), Bowman
patent: 6489316 (2002-12-01), Sandanayaka et al.
patent: 780386 (1997-06-01), None
patent: 818442 (1998-01-01), None
patent: WO 9720824 (1997-06-01), None

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