Peptides for inhibition of apoptosis and pharmaceutical...

Details Peptides for inhibition of apoptosis and pharmaceutical... Peptides for inhibition of apoptosis and pharmaceutical...

2005-02-01

2005-02-01

Wax, Robert A. (Department: 1653)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S328000

Reexamination Certificate

active

06849603

ABSTRACT:
The present invention relates to an isolated and purified peptide of the RY domain having an amino acid sequence of general formula (I) comprising a sequence of the following amino acids: X1—X2—X3—X4—X1—X4—X4—X3—X1, X1=Phe, Tyr, or any amino acid having a substituted aromatic residue; X2=Glu, Asp, Ser, or any amino acid having a —(CH2)n—COO residue, wherein n=0-3; X3=Asp, Thr, any aliphatic amino acid, or any of amino acids X4; and X4=Arg, Lys, or any amino acid having a —(CH2)n—NH3+residue, or a —(CH2)n—NH—C(NH3+)NH2residue wherein n=0-4; as well as functional equivalents thereof. The invention relates also to pharmaceutical compositions comprising a compound of general formula (I), the use of said RY peptide and of said pharmaceutical composition in the preparation of a medicament and in method for the treatment of disorders of inappropriate activation of apoptosis; for increasing the number of viable cells in a biological tissue; and in a method for the enhancement for the survival of biological cells. The invention also relates to a method for the preparation of a RY-peptide of general formula (I). Furthermore, the invention also relates to an in vitro assay system for the regulation of cell death by the Bcl-2 family of test compounds (as hereinbefore defined).

REFERENCES:
patent: 5910442 (1999-06-01), Gelman
patent: 6713280 (2004-03-01), Huang et al.
patent: 0 755 516 (1997-12-01), None
patent: 125908 (1998-08-01), None
patent: WO 9534315 (1995-12-01), None
patent: WO 9629403 (1996-09-01), None
patent: WO 9701760 (1997-01-01), None
patent: WO 9735971 (1997-10-01), None
patent: WO 9805777 (1998-02-01), None
S.M. Muchmore et al., “X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death”, Letters to Nature, vol. 381, May 23, 1996, pp. 335-341.

Affiliated with

Also associated with

Rating

Peptides for inhibition of apoptosis and pharmaceutical... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides for inhibition of apoptosis and pharmaceutical..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides for inhibition of apoptosis and pharmaceutical... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3451586