Derivatives of nicotinic acid with amines variously substituted

Details Derivatives of nicotinic acid with amines variously substituted Derivatives of nicotinic acid with amines variously substituted

1976-02-02

1977-05-03

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602955A, 424266, C07D21356

Patent

active

040214362

ABSTRACT:
A novel thionicotinate of nicotinamide is disclosed having the formula: ##STR1## The compound has the useful pharmacological activity of lowering cholesterol, free fatty acid and triglyceride plasma levels. In cases of liver injury, administration of the compound has modified toward normal the injury-induced malfunction of the liver. A synthesis of the compound from nicotinoyl chloride hydrochloride is described as well as modes for the administration of the compound.

REFERENCES:
patent: 2493645 (1950-01-01), Schlapfer
patent: 3155672 (1964-11-01), Pasini et al.

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