MDA-9 and uses thereof

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Reexamination Certificate

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C435S006120, C435S007100

Reexamination Certificate

active

06866993

ABSTRACT:
Increased expression of MDA-9 is associated with drug resistance of certain cells (e.g., cancer cells). The invention provides methods for identifying drug resistant cells by measuring the expression or activity of MDA-9, methods for identifying modulators of drug resistance, and methods for modulating drug resistance by modulating the expression or activity of MDA-9.

REFERENCES:
patent: 6071696 (2000-06-01), Fisher
patent: WO 9849290 (1998-11-01), None
Abstract of Stromskaya et al (Experimental and Toxicologic Pathology, 1995, vol. 47, pp. 157-166).*
Smith et al (The Journal of Biological Chemistry, 1995, vol. 270, pp. 28145-28152).*
Abstract of Zamboni et al (Clinical Cancer Research, 1998, vol. 4, pp. 743-753).*
Abstract of Zhou et al (Drugs, 1992, vol. 44, suppl. 4, pp. 1-16).*
Sadasivan et al, Cancer Letters, 1991, vol. 57, pp. 165-171.*
Berger et al, Journal of Medicinal Chemcistry, 1999, vol. 42, pp. 2145-2161.*
A. Branch, “A hitchhiker's guide to antisense and nonantisense biochemical pathways”, Hepatology, vol. 24, pp. 1517-1529, 1996.*
Broaddus et al, “Strategies for the design and delivery of antisense oligonucleotides in central nervous system”, Methods in Enzymology, vol. 314, pp. 121-135, 2000.*
Bertram et al, “Elevated expression of S100P, CAPL and MAGE3 in doxorubicin-resistant cell lines”, Anti-Cancer Drugs, vol. 9, pp. 311-317, Apr. 1998.*
Grootjans et al., “Syntenin, a PDZ protein that binds syndecan cytoplasmic domains” Proc. Nat'l. Acad. Sci. USA 94(25):13683-13688, 1997.
Harris et al., “Mechanisms of multidrug resistance in cancer treatment” Acta Oncologica 31(2):205-213, 1992.
Lin et al., “Characterization of a novel melanoma differentiation-associated gene, mda-9, that is . . . ” Mol. And Cell. Differentiation 4(4):317-333, 1996.
Scotto et al., “Amplification and expression of genes associated with multidrug resistance in mammalian cells” Science 232:751-755, 1986.
Simon et al., “Cell biological mechanisms of multidrug resistance in tumors” Proc. Nat'l. Acad. Sci. USA 91:3497-3504, 1994.
Waxman, J., “A new understanding of the hormonal regulation of endocrine dependant cancer” British Medical Bulletin 47(1):197-208, 1991.
GenBank Accession No. AF000652, Grootjans et al., Jan. 20, 1998.
GenBank Accession No. U83463, Burbelo, Apr. 2, 1997.
GenBank Accession No. AF006636, Lin et al., Mar. 18, 1998.

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