Derivative of nicotinic acid with amides

Details Derivative of nicotinic acid with amides Derivative of nicotinic acid with amides

1976-03-19

1977-05-03

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602955A, 424266, C07D21356

Patent

active

040214338

ABSTRACT:
A novel cysteine thiolactone of nicotinamide is disclosed having the formula: ##STR1## The compounds, homo-cysteine thiolactone of nicotinamide, and its pharmacologically acceptable salts have the useful pharmacological activity of lowering cholesterol, free fatty acid and triglyceride plasma level in the case of altered lipid metabolism and improving BSP clearance ratio in cases of liver injury.
A synthesis of the compound from nicotinoyl chloride, hydrochloride or nicotinic acid esters is described as well as modes for the administration of the compound.

REFERENCES:
patent: 3155672 (1964-11-01), Pasini et al.
patent: 3758485 (1973-09-01), Biniecki et al.

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