Process for producing 2,5-bis(trifluoromethyl)nitrobenzene

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

Reexamination Certificate

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C568S927000, C546S077000

Reexamination Certificate

active

06930214

ABSTRACT:
A process to produce 2,5-bis(trifluoromethyl)nitrobenzene in a high yield from an industrially easily available material by using a substance with which the reaction operation is simple and handling is easy, with a small number of steps under moderate reaction conditions, is provided. 1,4-bis(trifluoromethyl)benzene is nitrated by means of nitric acid in a solvent comprising as an essential component an acid selected from sulfuric acid having a sulfuric acid concentration of from 91 to 100 mass % and fuming sulfuric acid having a sulfur trioxide concentration of higher than 0 mass % and at most 20 mass %.

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patent: 09 031030 (1997-02-01), None
S. D. Ross, et al., “Tetrakis-(trifluoromethyl)-biphenyls”, J. Am. Chem. Soc., v. 75, pp. 4976-4969 (1953), XP002309512.
K. Yates, et al., “A Critical Test of the Hammett Acidity Function”, Can. J. Chem., v. 50, No. 4, pp. 581-583, (1972), XP002967660.
Clark et al, Tetrahedron Lett., vol. 30, p. 2133-2136 (1989).
Ross et al, J. Amer. Chem. Soc., vol. 75, p. 4967-4969 (1953).
Olah et al, J. Org. Chem., vol. 60, p. 7348-7350 (1995).
Yates et al., Canadian Journal of Chemistry, vol. 50, p. 581-583 (1972).

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