Methods for selecting polynucleotides encoding T cell epitopes

Details Methods for selecting polynucleotides encoding T cell epitopes Methods for selecting polynucleotides encoding T cell epitopes

2005-03-29

2005-03-29

Chan, Christina (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S007230, C435S006120

Reexamination Certificate

active

06872518

ABSTRACT:
The present invention relates to methods for the identification of antigens recognized by cytotoxic T cells (CTLs) and specific for human tumors, cancers, and infected cells, and the use of such antigens in immunogenic compositions or vaccines to induce regression of tumors, cancers, or infections in mammals, including humans. The invention encompasses methods for induction and isolation of cytotoxic T cells specific for human tumors, cancers and infected cells, and for improved selection of genes that encode the target antigens recognized by these specific T cells. The invention also relates to differential display methods that improve resolution of, and that reduce the frequency of false positives of DNA fragments that are differentially expressed in tumorous, cancerous, or infected tissues versus normal tissues. The invention further relates to the engineering of recombinant viruses as expression vectors for tumor, cancer, or infected cell-specific antigens.

REFERENCES:
patent: 4690915 (1987-09-01), Rosenberg
patent: 5166057 (1992-11-01), Palese et al.
patent: 5494807 (1996-02-01), Paoletti et al.
patent: 5530096 (1996-06-01), Wolfell et al.
patent: 5578473 (1996-11-01), Palese et al.
patent: 5804382 (1998-09-01), Sytkowski et al.
patent: 5843648 (1998-12-01), Robbins et al.
patent: 5866383 (1999-02-01), Moss et al.
patent: 5874560 (1999-02-01), Kawakami et al.
patent: WO 9533835 (1995-12-01), None
patent: WO 9724438 (1997-07-01), None
patent: WO 9726328 (1997-07-01), None
patent: WO 9734143 (1997-09-01), None
patent: WO 9930151 (1999-06-01), None
Tourway & Travers, ImmunoBiology p. 4:2-4:3, 1994.*
Sambrook et al. Molecular Cloning p. 8.51, 1989.*
Palese et al., 1996, “Negative-Strand RNA Viruses: Genetic Engineering and Applications”, Proc. Natl. Acad. Sci. USA 93:11354-11358.
Quill, 1996, “Anergy as a Mechanism of Peripheral T Cell Tolerance”, J. Immunol. 156:1325-1327.
Sidney et al., 1996, “Practical, Biochemical and Evolutionary Implications of the Discovery of HLA Class Supermotifs”, Imunnol. Today 17:261-266.
Wentworth et al., 1996, “Differences and Similarities in the A2.1-Restricted Cytotoxic T Cell Repertoire in Humans and Human Leukocyte Antigen-Transgenic Mice”, Eur. J. Immunol. 26:97-101.
Boel et al., 1995, “BAGE: A New Gene Encoding an Antigen Recognized on Human Melanomas by Cytolytic T Lymphocytes”, Immunity 2:167-175.
LaFace et al., 1995, “Human CD8 Transgene Regulation of HLA Recognition by Murine T Cells”, J. Exp. Med. 182:1315-1325.
Pfleiderer et al., 1995, “A Novel Vaccina Virus Expression System Allowing Construction of Recombinants without the Need for Selection Markers, Plasmids and Bacterial Hosts”, J. Gen. Virol. 76:2957-2962.
Shirai et al., 1995, “CTL Responses of HLA-A2.1-Transgenic Mice Specific for Hepatitis C Viral Peptides Predict Epitopes for CTL of Humans Carrying HLA-A2.1”, J. Immunol. 154:2733-2742.
Van der Eynde, 1995, “A New Family of Genes Coding for an Antigen Recognized by Autologues Cytolytic T Lymphocytes on a Human Melanoma”, J. Exp. Med. 182:689-698.
de Bergeyck et al., 1994, “An Intracisternal A-Particle Sequence Codes for an Antigen Recognized by Syngenic Cytolytic T Lymphocytes on a Mouse Spontaneous Leukemia”, Eur. J. Immunol. 24:2203-2212.
Huang et al., 1994, “Role of Bone Marrow-Derived in Presenting MHC Class 1-Restricted Tumor Antigens”, Science 264:961-965.
Kawakami et al., 1994, “Cloning of the Gene Coding for a Shared Human Melanoma Antigen Recognized by Autologous T Cells Infiltrating Into Tumor”, Proc. Natl. Acad. Sci. USA 91:3515-3519.
Brichard et al., 1993, “The Tyrosinase Gene Codes for an Antigen Recognized by Autologous Cytolytic T Lymphocytes on HLA-A2 Melanomas”, J. Exp. Med. 178:489-495.
Inaba et al., 1993, “Dendritic Cell Progenitors Phagocytose Particulates, Including Bacillus Calmette-Guerin Organisms, and Sensitize Mice to Mycobacterial Antigens In Vivo”, J. Exp. Med. 178:479-488.
Lisitsyn et al., 1993, “Cloning the Differences Between Two Complex Genomes”, Science 259:946-951.
Ralph et al., 1993, “RNA Fingerprinting Using Arbitrarily Primed PCR Identifies Differently Regulated RNAs in Milk Lung (MyLu) Cells Growth Arrested by Transforming Growth Factor β1”, Proc. Natl. Acad. Sci USA 90:10710-10714.
Sahasrabudhe et al., 1993, “Shared T Cell-Defined Antigens on Independently Derived Tumors”, J. Immunol. 151:6202-6210.
Inaba et al., 1992, “Generation of Large Numbers of Dendritic Cells from Mouse Bone Marrow Cultures Supplemented with Granulocyte/Macrophage Colony-Stimulating Factor”, J. Exp. Med. 176:1693-1702.
Liang et al., 1992, “Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction”, Science 257:967-971.
Merchlinsky et al., 1992, “Introduction of Foreign DNA into the Vaccinia Virus Genome by In Vitro Ligation: Recombination-Independent Selecatable Cloning Vectors”, Virology 190:522-526.
Scheiflinger et al., 1992, “Construction of Chimeric Vaccina Viruses by Molecular Cloning and Packaging”, Proc. Natl. Acad. Sci. USA 89:9977-9981.
Welsh et al., 1992, “Arbitrarily Primed PCR Fingerprinting of RNA”, Nucl. Acids Res. 20:4965-4970.
Meyer et al., 1991, “Mapping of Deletions in the Genome of the Highly Attenuated Vaccina Virus MVA and their Influence on Virulence”, J. Gen. Virol. 72:1031-1038.
Moss et al., 1991, “Vaccina Virus: A Tool for Research and Vaccine Development”, Science 252:1662-1667.
Torigoe et al., 1991, “Tumor Rejection Antigens on BALB3T3 Cells Transformed by Activated Oncogenes”, J. Immunol. 147:3251-3258.
Van der Bruggen et al., “A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma”, 1991, Science 254:1643-1647.
Vitiello et al., “Analysis of the HLA-Restricted Influenza-Specific Cytotoxic T Lymphocyte Response in Transgenic Mice Carrying a Chimeric Human-Mouse Class 1 Major Histocompatibility Complex”, 1991, J. Exp. Med. 173:1007-1015.
Bennink et al., “Recombinant Vaccina Viruses as Vectors for Studying T Lymphocyte Specificity and Function”, 1990, Curr. Top. Microbiol. Immunol. 163:153-184.
Kuff et al., “The Intracisternal A-Particle Gene Family: Structure and Functional Aspects”, 1988, Adv. Cancer Res. 51:183-277.
Aota et al., “Nucleotide Sequence and Molecular Evolution of Mouse Retrovirus-Like IAP Elements”, 1987, Gene 56:1-12.
Wolfel et al., 1987, “Immunogenic (tum) Variants Obtained by Mutagenesis of Mouse Mastocytoma P815”, Immunogenetics 26:178-187.
Macket et al., 1984, “General Method for Production and Selection of Infectious Vaccina Virus Recombinants Expressing Foreign Genes”, J. Virol. 49:857-864.
Macket et al., 1982, “Vaccina Virus: A Selectable Eukaryotic Cloning and Expression Vector”, Proc. Natl. Acad. Sci. USA 79:7415-7419.
Panicali et al., 1982, “Construction of Poxviruses as Cloning Vectors: Insertion of the Thymidine Kinase Gene from Herpes Simplex Virus into the DNA of Infectious Vaccina Virus”, Proc. Nat. Acad. Sci. USA 79:4927-4931.
Wilson et al., 1972, “A Novel DNA Polymerase Activity Found in Association with Intracisternal A-Type Particles”, Proc. Natl. Acad. Sci. USA 69:1531-1536.
Merchlinsky, M. et al., “Construction and Characterization of Vaccinia Direct Ligation Vectors,”Virology 238:444-451 (Nov. 1997).
Sahasrabudhe, D.M. et al., “Shared T Cell-Defined Antigens on Independently Derived Tumors,”J. Immunol. 151:6302-6310 (1993).
Takahashi, H. et al., “Induction of CD8+cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs,”Nature 344:873-875 (1990).
Traversari, C., et al., “Transfection and expression of a gene coding for a human

Affiliated with

Also associated with

Rating

Methods for selecting polynucleotides encoding T cell epitopes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods for selecting polynucleotides encoding T cell epitopes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for selecting polynucleotides encoding T cell epitopes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3448766