Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-10-04
2005-10-04
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S275400, C546S276100
Reexamination Certificate
active
06951876
ABSTRACT:
This invention relates to a compound of the formula:or a pharmaceutically acceptable salt thereof, wherein A and R1are each an optionally substituted 5 to 6-membered heteroaryl, wherein the heteroaryl is optionally fused to a carbocyclic ring or 5 to 6-heteroaryl; R2is NH2; R3and R4are each hydrogen, halo, (C1-C4)alkyl optionally substituted with halo and the like; and X1to X4are each hydrogen, halo, hydroxy, (C1-C4)alkyl optionally substituted with halo and the like. These compounds have COX-2 inhibiting activity and thus useful for treating or preventing inflammation or other COX-2 related diseases.
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Vane, J.R.; Mitchell, J.A.; Appleton, I.; Tomlinson, A.; Bishop-Bailey, D.; Croxtoll, J.; Willoughby, D.A.Proc. Natl. Acad. Sci. USA1994, 91, 2046.
Ando Kazuo
Kawamura Kiyoshi
Benson Gregg C.
Hosley Mary J.
Morris Patricia L.
Pfizer Inc.
Richardson Peter
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