Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-10-04
2005-10-04
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C536S023500, C536S024310, C536S024330
Reexamination Certificate
active
06951724
ABSTRACT:
The present invention is directed to a method of screening large, complex, polyexonic eukaryotic genes such as the ATM gene for mutations and polymorphisms by an improved version of single strand conformation polymorphism (SSCP) electrophoresis that allows electrophoresis of two or three amplified segments in a single lane. The present invention also is directed to new mutations and polymorphisms in the ATM gene that are useful in performing more accurate screening of human DNA samples for mutations and in distinguishing mutations from polymorphisms, thereby improving the efficiency of automated screening methods.
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Exhibit 5 is a publication, R.A. Gatti, “Ataxia-Telectangiasia”in Genetic Basis of Human Cancer(Vogelstein & Kinzler, eds., McGraw-Hill, New York, 1998).
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Exhibit 25 is a publication, M. Telatar et al., “Ataxia-Telangiectasia: Identification and Detection of Founder-Effect Mutations in theATMgene in Ethnic Populations,”Am. J. Hum. Genet.62:86-87 (1998).
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Exhibit 28 is a publication, L. Vorechovsky et al., “ATM Mutations in Cancer Families,”Cancer Res.56: 4130-4133 (1996).
Exhibit 29 is a publication, T. Dork et al., “A Frequent Polymorphism of the Gene Mutated in Ataxia-Telangiectasia,”Mol. Cell. Probes11:71-73 (1997).
Exhibit 30 is a publication, C. McConville et al., “Mutations Associated with Variant Phenotypes in Ataxia-Telangiectasia,”Am. J. Hum. Genet.59:329-330 (1996).
Exhibit 31 is a publication, M. Chillon et al., “Mutations in the Cystic Fibrosis Gene in Patients with Congenital Absence of the Vas Deferens,”N. Engl. J. Med.332:1475-1480 (1995).
Exhibit 32 is a publication, X. Estivill, “Complexity in a Monogenic Disease,”Nature Genet. 12:350 (1996). Exhibit 33 is a publication, S. Pedemonte et al., “Novel Germline APC Variants in Patients with Multiple Adenomas,”Genes Chromosomes Cancer22:257-267 (1998).
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Exhibit 36 is a publication, M. Telatar et al., “A Model for ATM Heterozygote Identification in a Large Population: Four Founder-Effect ATM Mutations Identify Most of Costa Rican Patients with Ataxia Telangiectasia,”Mol. Genet . Metabol.64: 36-43 (1998).
Exhibit 37 is a publication, M.F. Lavin et al., “Eighth International Workshop on Ataxia-Telangiectasia (ATW8),”Cancer Res.59: 3845-3849 (Aug. 1, 1999). Exhibit 37 is not prior art, as it was published after the filing date of above-identified application. It is being provided for convenience only.
Exhibit 38 is a publication, K.M. Cerosaletti et al., “Fine Localization of the Nijmegen Breakage Syndrome Gene to 8q21: Evidence for a Common Founder Haplotype,”Am. J. Hum. Genet.63: 125-134 (1998).
Exhibit 39 is a publication, M. Telatar et al., “Atasia-Telangiectasia: Identification and Detection of Founder-Effect Mutations in the ATM Gene in Ethnic Populations,”Am. J. Hum. Genet.62:86-97 (1998).
Horlick Kenneth R.
Knobbe Martens Olson and Bear
The Regents of the University of California
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