Peptide inhibitors of Hepatitis C virus NS3 protein

Details Peptide inhibitors of Hepatitis C virus NS3 protein Peptide inhibitors of Hepatitis C virus NS3 protein

2005-01-25

2005-01-25

Tate, Christopher R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

06846806

ABSTRACT:
This invention relates to a novel class of peptides having the Formula (I):which are useful as serine protease inhibitors, and more particularly as Hepatitis C virus(HCV) NS3 protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same in the treatment of HCV infection.

REFERENCES:
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P. Ingallinella, et al, “Potent Peptide Inhibitors of Human Hepatitis C Virus NS3 Protease Are Obtained by Optimizing the Cleavage Products,” Biochemistry, 37, pp. 8906-8914, 1998.
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