Pyrimidine derivatives

Details Pyrimidine derivatives Pyrimidine derivatives

2005-01-25

2005-01-25

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S269000, C514S217060, C514S227800, C514S231500, C544S326000, C544S328000, C544S111000, C544S060000, C540S598000

Reexamination Certificate

active

06846827

ABSTRACT:
The invention concerns pyrimidine derivatives of Formula (I) wherein m is 0-3 and each R1is a group such as hydroxy, halogeno, trifluoromethyl and cyano; R3is hydrogen, halogeno or (1-6C)alkyl; n is 0-2 and each R2is a group such as hydroxy, halogeno, trifluoromethyl and cyano; p is 0-4; and Q1is aryl or heteroaryl; or pharmaceutically acceptable salts or in vivo cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

REFERENCES:
patent: 0 566 226 (1993-10-01), None
patent: 0 945 443 (1999-09-01), None
patent: WO 9733883 (1997-09-01), None
patent: 9822103 (1998-05-01), None
patent: WO 9901439 (1999-01-01), None
patent: 9915164 (1999-04-01), None
patent: 9959959 (1999-11-01), None
patent: 9959960 (1999-11-01), None
patent: 0007980 (2000-02-01), None
patent: 0007991 (2000-02-01), None
patent: 0012485 (2000-03-01), None
patent: 0012486 (2000-03-01), None
patent: WO 0012487 (2000-03-01), None
patent: 0018738 (2000-04-01), None
patent: 0020402 (2000-04-01), None
patent: WO 0020402 (2000-04-01), None
patent: 0055120 (2000-09-01), None
patent: 0055153 (2000-09-01), None
patent: 0056738 (2000-09-01), None
Shaw et al. Expert Opin. Investig. Drugs 9(7) 1469-1478, 2000.*
Brunet et al., Essays Biochem. 32 : 1-16, 1997.*
Nagarkatti et al. J. Mol. Cell Cardiol. 30(8): 1651-1664, 1998.*
Herlaar et al. Mol. Med. Today 5(10) 439-447, 1999.*
Graninger et al., Curr. Opin. Rheumatol. 13(3): 209-213, 2001.*
Hansen, “Review—Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis—Inhibitors of p38 kinase”, Exp. Opin. Ther. Patents, 1997, XP-002086152, pp. 729-733.

Affiliated with

Also associated with

Rating

Pyrimidine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrimidine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrimidine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3438831