Process for preparation of 5-hydroxymethylthiazole

Details Process for preparation of 5-hydroxymethylthiazole Process for preparation of 5-hydroxymethylthiazole

1996-05-22

1998-01-27

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27724, C07D27722

Patent

active

057124000

ABSTRACT:
A process for the preparation of 5-hydroxymethylthiazole comprises reacting a compound of the formula, ##STR1## with a carboxylic acid salt (optimally in the presence of a quaternary ammonium salt) and hydrolyzing the resulting ester. Subsequent dechlorination gives 5-hydroxymethylthiazole.

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Noyce, et al., J. Org. Chem. 38, 3316 (1973).

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