HRPCa9 and HRPCa10 nucleic acids and polypeptides

Details HRPCa9 and HRPCa10 nucleic acids and polypeptides HRPCa9 and HRPCa10 nucleic acids and polypeptides

2005-03-29

2005-03-29

Ungar, Susan (Department: 1642)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S252300

Reexamination Certificate

active

06872811

ABSTRACT:
The invention concerns cDNA molecules encoding HRPCa 9 and HRPCa 10 both of which are constitutively expressed in the androgen-independent cell line, LN3 LNAcP and induced by testosterone in the androgen-dependent cell line, LNAcP.The invention provides isolated nucleic acid molecules encoding a polypeptide of the invention or biologically active portion thereof. The present invention also provides nucleic acid molecules which are suitable as primers or hybridization probes for the detection of nucleic acids encoding a polypeptide of the invention. The invention also provides screening assays which can be used to identify compounds useful for the treatment of prostate cancer (e.g., androgen-independent prostate cancer).

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