Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-03-22
2005-03-22
Stucker, Jeffrey (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388100, C530S389100, C530S391100, C435S005000, C435S007920, C435S975000
Reexamination Certificate
active
06870032
ABSTRACT:
The invention concerns a method for early detection of aflavivirus-induced infection, comprising the detection of theflavivirusnon-structural glycoprotein NS1 in a biological sample during the clinical phase of the infection, by an immunological method using at least two identical or different antibodies, the first antibody consisting of polyclonal or monoclonal antibodies pre-selected for their high affinity for said NS1 protein hexameric in shape.
REFERENCES:
patent: 4281061 (1981-07-01), Zuk et al.
patent: 0 402 116 (1990-12-01), None
patent: WO 9322440 (1993-11-01), None
Tijssen. Laboratory Techniques in Biochemistry and Molecular Biology: Practice and Theory of Enzyme Immunoassays, vol. 15 (New York, Elsevier, 1985). pp. 14-17.*
Harlow et al.Antibodies: A Laboratory Manual. N.Y., Cold Spring Harbor, 1988. pp. 578-579. QR186.7.A53.*
Fields.Fields Virology, 3rdedition, (Philadelphia, PA, Lippincott Williams & Wilkins, 1995), pp. 990, 998, 999, and 1012.*
Crooks, Alan J. et al., , “The NS1 Protein of Tick-Borne Encephalitis Virus Forms Multimeric Species Upon Secretion From The Host Cell” Journal of General Virology (1994), 75. pp. 3453-3460.
Falconar, A.K.I., et al., “Precise Location of Sequential Dengue Virus Subcomplex And Complex B Cell Epitopes On The Nonstructural-1 Glycoprotein”, Arch Virol (1994) 137: pp. 315-326.
Falconar, A.K.I., et al., “Production of Dimer-Specific and Dengue Virus Group Cross-Reactive Mouse Monoclonal Antibodies to the Dengue 2 Virus Non-Structural Glycoprotein NS1”, Short Communication, (1991) pp. 962-965.
Falconar, A.K.I., “Immunoaffinity Purification of Native Dimer Forms of the Flavivirus Non-Structural Glycoprotein, NS1”, Journal of Virological Methods, 30 (1990) pp. 323-332.
Jacobs, S.C., et al., “ High -Level Expression of the Tick-Borne Encephalitis Virus NS1 Protein by Using an Adenovirus-Based Vector: Protection Elicited in a Murine Model”, Journal of Virology, Apr. (1992) pp. 2086-2095.
Flamand, M. et al., “Purification and Renaturation of Japanese Encephalitis Virus Nonstructural Glycoprotein NS1 Overproduced by Insect Cells”, Protein Expression and Purification 6, (1995) pp. 519-527.
Hall, R.A. et al., “Immunoaffinity Purification of the NS1 Protein of Murray Valley Encephalitis Virus: Selection of the Appropriate Ligand and Optimal Conditions for Elution”, Journal of Virological Methods, 32 (1991) pp. 11-20.
Alcon Sophie
Despres Philippe
Deubel Vincent
Flamand Marie
Megret Françoise
Finnegan Henderson Farabow Garrett & Dunner LLP
Institut Pasteur
Stucker Jeffrey
LandOfFree
Assay for the diagnosis of flaviviral infection using... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Assay for the diagnosis of flaviviral infection using..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Assay for the diagnosis of flaviviral infection using... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3431338