Antibodies to human chemotactic protein

Details Antibodies to human chemotactic protein Antibodies to human chemotactic protein

2005-03-15

2005-03-15

Kemmerer, Elizabeth (Department: 1646)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C530S387100, C530S387300, C530S388100, C530S388150, C530S388230, C530S388240, C530S389100, C530S389200, C530S391100, C530S391300

Reexamination Certificate

active

06867006

ABSTRACT:
A human chemotactic polypeptide, DNA (RNA) encoding it, and a procedure for producing such a polypeptide by recombinant techniques are disclosed. Also disclosed are methods of using the polypeptide for a number of purposes, including: stem cell mobilization, myeloprotection, neuronal protection, treating tumors, wound healing, treating parasitic infection, and regulating hematopoiesis. Also disclosed are polypeptide antagonists and diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.

REFERENCES:
patent: 5179078 (1993-01-01), Rollins et al.
patent: 5237051 (1993-08-01), Garbers et al.
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5382658 (1995-01-01), Kronis et al.
patent: 5459128 (1995-10-01), Rollins et al.
patent: 5866373 (1999-02-01), Li et al.
patent: 5880263 (1999-03-01), Li et al.
patent: 6028169 (2000-02-01), Kreider et al.
patent: 6075124 (2000-06-01), Li et al.
patent: 6100389 (2000-08-01), Li et al.
patent: 6174995 (2001-01-01), Li et al.
patent: 6379926 (2002-04-01), Kreider et al.
patent: 6419917 (2002-07-01), Li et al.
patent: 2 152 141 (1996-12-01), None
patent: 0 488 900 (1992-06-01), None
patent: WO-9808777 (1990-08-01), None
patent: WO 9220372 (1992-11-01), None
patent: WO 9507985 (1995-03-01), None
patent: WO 9531467 (1995-11-01), None
patent: WO 9638559 (1996-12-01), None
patent: WO 9640762 (1996-12-01), None
patent: WO 9715594 (1997-05-01), None
patent: WO-9844118 (1998-10-01), None
Beall, C.J., et al., “Conversion of Monocyte Chemoattractant Protein-1 into a Neutrophil Attractant by Substitution of Two Amino Acids,”J. Biol. Chem. 267:3455-3459, American Society for Biochemistry and Molecular Biology, Inc. (1992).
Berkhout, T.A., et al., “Cloning, in Vitro Expression, and Functional Characterization of a Novel Human CC Chemokine of the Monocyte Chemotactic Protein (MCP) Family (MCP-4) That Binds and Signals through the CC Chemokine Receptor 2B,”J. Biol. Chem. 272:16404-16413, American Society for Biochemistry and Molecular Biology, Inc. (Jun. 1997).
Bischoff, S.C., et al., “Monocyte Chemotactic Protein 1 Is a Potent Activator of Human Basophils,”J. Exp. Med. 175: 1271-1275, Rockefeller University Press (1992).
Bork, P., and Bairoch, A., “Go hunting in sequence databases but watch out for the traps,”Trends Genet. 12:425-427, Elsevier Science B.V. (Oct. 1996).
Bork, P., “Powers and Pitfalls in Sequence Analysis: The 70% Hurdle,”Genome Res. 10:398-400, Cold Spring Harbor Laboratory Press (Apr. 2000).
Bottazzi, B., et al., “A chemoattractant expressed in human sarcoma cells (tumor-derived chemotactic factor, TDCF) is identical to monocyte chemoattractant protein-1/monocyte chemotactic and activating factor (MCP-1/MCAF),”Int. J. Cancer 45:795-797, Wiley-Liss, Inc. (1990).
Bowie, J.U., et al., “Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions,”Science 247:1306-1310, American Association for the Advancement of Science (1990).
Brenner, S.E., “Errors in genome annotation,”Trends Genet. 15:132-133, Elsevier Science B.V. (Apr. 1999).
Brieland, J.K., et al., “Effect of Acute Inflammatory Lung Injury on the Expression of Monocyte Chemoattractant Protein-1 (MCP-1) in Rat Pulmonary Alveolar Macrophages,”Am. J. Respir. Cell Mol. Biol. 7:134-139, American Lung Association (1992).
Brieland, J.K., et al., “Expression of Monocyte Chemoattractant Protein-1 (MCP-1) by Rat Alveolar Macrophages during Chronic Lung Injury,”Am. J. Respir. Cell Mol. Biol. 9:300-305, American Lung Association (1993).
Brown, Z., et al., “IL-1 receptor antagonist inhibits monocyte chemotactic peptide-1 generation by human mesangial cells,”Kidney Int. 42:95-101, Blackwell Scientific Publications (1992).
Colditz, I., et al., “In VivoInflammatory Activity of Neutrophil-Activating Factor, a Novel Chemotactic Peptide Derived from Human Monocytes,”Am. J. Pathol. 134:755-760, American Association of Pathologists (1989).
Daniel, C., et al., “Mapping of Linear Antigenic Sites on the S Glycoprotein of a Neurotropic Murine Coronavirus with Synthetic Peptides: A Combination of Nine Prediction Algorithms Fails To Identify Relevant Epitopes and Peptide Immunogenicity Is Drastically Influenced by the Nature of the Protein Carrier,”Virology 202:540-549, Academic Press, Inc. (Aug. 1994).
Decock, B., et al., “Identification of the Monocyte Chemotactic Protein from Human Osteosarcoma Cells and Monocytes Detection of a Novel N-Terminally Processed Form, ”Biochem. Biophys. Res. Commun. 167:904-909, Academic Press, Inc. (1990).
Doerks, T., et al., “Protein annotation: detective work for function prediction,”Trends Genet. 14:248-250, Elsevier Science B. V. (Jun. 1998).
Forssmann, U., et al., “Eotaxin-2, a Novel CC Chemokine that Is Selective for the Chemokine Receptor CCR3, and Acts Like Eotaxin on Human Eosinophil and Basophil Leukocytes,”J. Exp. Med. 185:2171-2176, Rockefeller University Press (Jun. 1997).
Furutani, Y., et al., “Cloning and Sequencing of the cDNA for Human Monocyte Chemotactic and Activating Factor (MCAF),”Biochem. Biophys. Res. Commun. 159:249-255, Academic Press, Inc. (1989).
Garcia-Zepeda, E.A., et al., “Human Monocyte Chemoattractant Protein (MCP)-4 Is a Novel CC Chemokine with Activities on Monocytes, Eosinophils, and Basophils Induced in Allergic and Nonallergic Inflammation That Signals Throught the CC Chemokine Receptors (CCR)-2 and -3,”J. Immunol. 157:5613-5626, American Association of Immunologists, Inc. (Dec. 1996).
George, D.G., et al., “Current Methods in Sequence Comparison and Analysis,” inMacromolecular Sequencing and Synthesis, Selected Methods and Applications, Schlesinger, D.H., ed., Alan R. Liss, Inc., New York, New York, pp. 127-149 (1988).
Gong, J.-M., and Clark-Lewis, I., “Antagonists of Monocyte Chemoattractant Protein 1 Indentified by Modification of Functionally Critical NH2-terminal Residues,”J. Exp. Med. 181:631-640, Rockefeller University Press (Feb. 1995).
Gong, J.-H., et al., “RANTES and MCP-3 Antagonists Bind Multiple Chemokine Receptors,”J. Biol. Chem. 271:10521-10527, American Society for Biochemistry and Molecular Biology, Inc. (May 1996).
Gronenborn, A.M., and Clore, G.M., “Modeling the three-dimensional structure of the monocyte chemo-attractant and activating protein MCAF/MCP-1 on the basis of the solution structure of interleukin-8,”Protein Eng. 4:263-269, Oxford University Press (1991).
Jose, P.J., et al., “Eotaxin: A Potent Eosinophil Chemoattractant Cytokine Detected in a Guinea Pig Model of Allergic Airways Inflammation,”J. Exp. Med. 179:881-887, Rockefeller University Press (Mar. 1994).
Kao, J., et al., “Endothelial Monocyte-activating Polypeptide II. A Novel Tumor-Derived Polypeptide That Activates Host-Response Mechanisms,”J. Biol. Chem. 267:20239-20247, American Society for Biochemistry and Molecular Biology, Inc. (1992).
Kawahara, R.S., and Deuel, T.F., “Platelet-derived Growth Factor-inducible Gene JE Is a Member of a Family of Small Inducible Genes Related to Platelet Factor 4,”J. Biol Chem. 264:679-682, American Society for Biochemistry and Molecular Biology, Inc. (1989).
Koch, A.E., et al., “Enhanced Production of Monocyte Chemoattractant Protein-1 in Rheumatoid Arthritis,”J. Clin. Invest. 90: 772-779, American Society for Clinical Investigation, Inc. (1992).
Kuna, P., et al., “Monocyte Chemotactic and Activating Factor Is a Potent Histamine-releasing Factor for Human Basophils,”J. Exp. Med. 175:489-493, Rockefeller University Press (1992).
Marston, F.A.O., “The purification of eukaryotic polypeptides synthesized inEscherichia coli,” Biochem J. 240

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