Pentapeptide antibiotics

Details Pentapeptide antibiotics Pentapeptide antibiotics

1995-05-15

1997-02-11

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530322, C07K 764

Patent

active

056022298

ABSTRACT:
Pentapeptide antibiotics of the formula ##STR1## wherein W, Z, X.sub.1, X.sub.2 and T represent the relative portions of an antibiotic of the dalbaheptide group (glycopeptide antibiotics), Y represents a carboxyacid group, a functional derivative of a carboxyacid group or a hydroxymethyl group. The invention includes the salts of the above represented pentapeptide antibiotics with acids or bases as well as their inner salts.

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Kirk-Othmer, Encyclopedia of Chemical Technology, 3rd. Edition, vol. 2, John Wiley & Sons, p. 809 (1978).
N. Pant et al., J. Am. Chem. Soc. 110, pp. 2002-2003.
R. Nagarajan et al., J. Chem. Soc., Chem. Commun., pp. 1306-1307 (1988).

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