Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-01-25
2005-01-25
Harris, Alana M. (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S300000, C530S350000, C530S385000, C530S386000, C530S387100, C530S388100
Reexamination Certificate
active
06846911
ABSTRACT:
Isolated proteins comprising the T-cell surface antigen CD97 α are provided. Compositions and methods for making and detecting CD97 α are also provided. Further, the invention provides diagnostic and therapeutic methods and compositions for medical conditions involving CD97. The inventions also provides antibody compositions that bind specifically to CD97 α subunits.
REFERENCES:
patent: WO 9806838 (1998-02-01), None
Campbell, Ailsa M. Monoclonal antibody technology, Chapter 1, pp. 1-32, 1984.*
Amino acid database, Accession No. P48960. Sequence alignment between accession No. and Applicants' Seq ID No: 1, 2, 5 and 6, Feb. 1, 1996.*
Hamann, J. et al., “Expression Cloning and Chromosomal Mapping of the Leukocyte Activation Antigen CD97, a New Seven-Span Transmembrane Molecule of the Secretin Receptor Superfamily with an Unusual Extracellular Domain,”J. of Immunology, 155(4):1942-1950 (1995).
Hamann, J. et al., “Structure of the Human CD97 Gene: Exon Shuffling has Generated a new Type of Seven-Span Transmembrane Molecule Related to the Secretin Receptor Superfamily,”Genomics, 32(1):144-147 (1996).
Hamann, J. et al., “The Seven-Span Transmembrane Receptor CD97 has a Cellular Ligand (CD55, DAF),”J. of Experimental Medicine, 184(3):1185-1189 (1996).
Hamann, J. et al., “Expression Cloning of the Human CD97 Antigen,”J. of Cellular Biochemistry Supplement 0(21A):72 (1995).
Gray, J. et al., “CD97 is a Processed, Seven-Transmembrane, heterodimeric Receptor Associated with Inflammation,”J. of Immunology 157(12):5438-5447 (1996).
Eichler, W., et al., “Expression characteristics of the human CD97 antigen,”Tissue Antigens 50(5):429-438 (1997).
Aust, G., et al., “CD97: A Dedifferentiation Marker in Human Thyroid Carcinomas,”Cancer Research 57(9):1798-1806 (1997).
Amino acid database, Accession #P48960, updated Sep. 15, 2003; created Feb. 1, 1996.
Amino acid database, Accession #137225/P26706, updated Jul. 15, 1998; created Aug. 1, 1992.
Rojanasakul, Y., “Antisense oligonucleotide therapeutics: drug delivery and targeting,”Advanced Drug Delivery Reviews18:115-313 (1996).
Harris Alana M.
The United States of America as represented by the Department of
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