Indazole compounds, pharmaceutical compositions, and methods...

Details Indazole compounds, pharmaceutical compositions, and methods... Indazole compounds, pharmaceutical compositions, and methods...

2005-07-19

2005-07-19

Tsang, Cecilia J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

06919461

ABSTRACT:
Indazole compounds that modulate and/or inhibit cell proliferation, such as the activity of protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating, e.g., kinases-dependent diseases to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

REFERENCES:
“Some derivatives of 5-nitro and 5-amino-3-indazolecarboxylic acid”, Zh. Obshch. Khim., vol. 31, pp. 3255-3257, 1961.
Greene et. al., Protective Groups in Organic Synthesis, Wiley & Sons, Inc., p. 537.

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