Imidazole, triazole and tetrazole derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514320, 514324, 514383, 514359, 514397, 514402, 546196, 546202, 548254, 548255, 5482622, 5483114, A61K 3141, C07D40906

Patent

active

056021631

ABSTRACT:
A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

REFERENCES:
patent: 3475437 (1969-10-01), Landgraf et al.
patent: 3644403 (1972-02-01), Rodriquez et al.
patent: 3801594 (1974-04-01), Poletto et al.
patent: 4138570 (1979-02-01), Psaar
patent: 4453001 (1984-06-01), Brand et al.
patent: 4618617 (1986-10-01), Yamamato
patent: 4672067 (1987-06-01), Coates
patent: 4692531 (1987-09-01), Algieri et al.
patent: 4839377 (1989-06-01), Bays et al.
patent: 4851406 (1989-07-01), Mertens et al.
patent: 4870085 (1989-09-01), Glaser et al.
patent: 4881967 (1989-11-01), Semple
patent: 5037845 (1991-08-01), Oxford
patent: 5225431 (1993-07-01), Robertson
patent: 5436246 (1995-07-01), Bernotas
patent: 5492919 (1996-02-01), Sanger
A. Doenicke, et al. The Lancet, 1988, 1, 1309-11.
Design of Prodrugs, ed. H. Bundgaard, Elsevier, 1985.
Journal of Medicinal Chemistry, vol. 30, No. 1 Jan. 1987 Washington, U.S.R.A. Glenn, `Central Serotonin Receptors as Targets for Drug Research`.
Protective Groups In Organic Chemistry, ed. Plenum Press, 1973.
T. W. Greene, Protective Groups In Organic Synthesis, John Wiley & Sons, 1981.
J. Neurosci, 7, 894 (1987).
Arch. Pharm., 342, 111 (1990).
J. Org. Chem., vol. 47, p. 536-544 (1982) by Jose Elguero, et al., entitled Synthesis and Physicochemical Properties of 1, 2, b-Thiadiazine 1, 1-Dioxides.
Chem. Ber. vol. 111, p. 1915-1971 (1978) by M. Preiss, entitled 1, 2, 5-Thiadiazolidin-1, 1-dioxidund Homologe.
Indian J. of Chem., vol. 21B, pp 941-944 (10/82) by V. P. Arya, et al., entitled Nitroimidazoles: Part V-1[1-Methyl-5-nitroimidazol-2-yl]-1, 2-4-triazolidin-3, 5-diones & Analogues.
Moltzen et al. "Fused heterocyclobenzo 5HT1A receptor antagonists and agonists" CA 122:290887 (1994).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Imidazole, triazole and tetrazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazole, triazole and tetrazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazole, triazole and tetrazole derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-342591

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.