Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-04-17
1997-02-11
McKane, Joseph
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514340, 514342, 514372, 514373, 514379, 5462711, 5462721, 548207, 548214, 548241, 548248, A61K 3138, A61K 3142, A61K 31425
Patent
active
056021607
ABSTRACT:
Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents.
(+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl] isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.
REFERENCES:
The Merck Index, 11th Ed. 1989, p. 262, S. Budavari et al., Merck & Co., Inc. Rahway, US.
J. Org. Chem. vol. 52, No. 25, Dec. 18, 1987, pp. 5501-5505, Sauers et al., "Synthesis . . . Ketones", p. 5504.
CA 95628x: 102, No. 11, Mar. 18, 1985, p. 574.
Chem. and Pharmaceutical Bulletin, vol. 34, No. 4, 1986, pp. 1643-1655, Tatee et al., "Isoxazole . . . propanamides", p. 1646.
CA 67: 32649t Isoxazoles. XVIII. Synthesis . . . derivatives. Hideo et al., p. 3090, 1967.
CA 115: 114491j Aminoketone . . . thereof. Matsubara et al., p. 901, 1991.
CA 115: 207980h Process . . . 3-phenylisoxazoles. Matsubara et al., p. 1022, 1991.
Horikomi Kazutoshi
Kajiya Seitaro
Matsubara Akira
Mizuchi Akira
Ohto Norio
McKane Joseph
Mitsui Toatsu Chemicals Incorporated
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