Processes for cell traced based testing of biological cells

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

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C435S325000

Reexamination Certificate

active

06841356

ABSTRACT:
For the cell trace based testing of biological cells, wherein the cells (16) are applied to an at least partially structured and/or surface modified substrate (11) and move adhesively over surface track regions (13, 15) of the substrate while producing cell traces (14a,14b) consisting of material residues separated from the cells, cell tests are performed on the cell traces. A process for cell cultivation on biocompatible modified substrates whose surfaces are covered by cell traces is also described.

REFERENCES:
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patent: 5047321 (1991-09-01), Loken et al.
patent: 5962136 (1999-10-01), Dewez et al.
patent: 3119269 (1982-12-01), None
patent: 0 849 595 (1996-12-01), None
patent: 2743421 (1997-07-01), None
Chen W. Mechanism of Retraction of the Trailing Edge During Fibroblast Movement. J of Cell Biology 90(1)187-200, 1981.*
Fuhr G. Cell Traces . . . Biol Chem 379(8-9)1161-1173, Aug./Sep. 1998.*
Matsuda T. Control of Cell Adhesion, Migration, and Orientation on Photochemically Microprocessed Surfaces. J of Biomedical Materials Res 32(2)165-173, 1996.*
English translation of FR 2743421 by Ronfard et al.
E.D. Hay et al., “Interaction of Migrating Embryonic Cells with Extracellular Matrix”, Expl. Biol. Med., vol. 10, pp. 174-193 (Karger, Basel 1985).

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