Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Reexamination Certificate
2005-07-05
2005-07-05
Slobodyansky, Elizabeth (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
C435S023000, C435S024000
Reexamination Certificate
active
06913918
ABSTRACT:
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
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Bienkowski Michael J.
Gurney Mark E.
Heinrikson Robert L.
Parodi Luis A.
Yan Riqiang
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company
Slobodyansky Elizabeth
Wootton Thomas A.
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