Platelet aggregation inhibitors

Details Platelet aggregation inhibitors Platelet aggregation inhibitors

1995-01-17

1997-02-11

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5462791, 546329, 546330, C07D21336, C07D21356, C07D21357, A61K 3144

Patent

active

056021550

ABSTRACT:
This invention herein relates to compounds having the following formula ##STR1## or a pharmaceutically acceptable salt thereof which are useful in the inhibition of platelet aggregation, to pharmaceutical compositions containing the compound and to a method of inhibiting platelet aggregation in mammals by administering such compounds and compositions.

REFERENCES:
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 4952562 (1990-08-01), Klein et al.
Fok et al. "Aminopeptidase resistant Arg-Gly-Asp analogs are stable in plasma and inhibit platelet aggregation." Int. J. Peptide Protein Res., 38, 124-130 (1991).
Greenspoon et al. "Structural Analysis of Integrin-Mediated Cell Functions by Novel Nonpeptide Surrogates of the Arg-Gly-Asp Sequence." Biochemistry, 32, 1001-1008 (1993).
McDowell et al. "From Peptide to Non-Peptide. The Elucidation of a Bioactive Conformation of the Arg-Gly-Asp Acid Recognition Sequence." J. Am. Chem. Soc., 116, 5069-5076 (1994).

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