Cholesterol ester hydrolase inhibitors

Details Cholesterol ester hydrolase inhibitors Cholesterol ester hydrolase inhibitors

1995-12-15

1997-02-11

Gupta, Yogendra N.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514330, 546216, 546226, 546227, 546228, A61K 31445, C07D21106

Patent

active

056021518

ABSTRACT:
The compounds of the formula: ##STR1## in which X is ##STR2## where R.sup.7 is hydrogen, alkyl, hydroxy, alkanoyloxy, hydroxyalkyl, hydroxycarbonyl, alkoxycarbonyl, phenyl or substituted phenyl, in which the substituent is alkyl, alkoxy, halo, nitro, cyano, haloalkyl, perhaloalkyl or dialkylaminoalkyl; R.sup.8 is hydrogen or alkyl or R.sup.7 and R.sup.8 taken together are polymethylene; R.sup.9 is hydrogen, alkyl, phenyl or substituted phenyl, in which the substituent is alkyl, alkoxy, halo, nitro, cyano or perhaloalkyl; R.sup.10 is hydrogen, alkyl or gemdialkyl; n is one of the integers 0, 1 or 2; and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are, independently, hydrogen, alkyl, alkoxy, halo, nitro, cyano or perhaloalkyl, alkoxycarbonyl or hydroxycarbonyl; and when X is --NR.sup.9 -- or R.sup.7 is an amino alkyl group, a pharmaceutically acceptable salt thereof; are useful as inhibitors of cholesterol ester hydrolase.

REFERENCES:
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patent: 4491465 (1985-01-01), Takematsu et al.
Bhat et al., Biochem. Biophys. Res. Commun., 109, 486 (1982).
Gallo et al., J. Lipid Research, 25, 604 (1984).
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Stout et al., Biochem. Biophys. Acta, 837, 6 (1985).
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Cayen et al., J. Lipid Research, 20, 162 (1979).
Foldes et al., J. Pharmacol. Exptl. Therap. 122, 457-464 (1958).
Sumida et al., Plant & Cell Physiol. 14, 781-785 (1973).
van den Berg et al., Pestic. Sci. 13, 29-38 (1982).
Derwent Abstract 81-55962-D of Japanese Patent J56071-058.

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