NKA affecting piperidyl heterobicyclic compounds

Details NKA affecting piperidyl heterobicyclic compounds NKA affecting piperidyl heterobicyclic compounds

1994-12-02

1997-02-11

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514316, 514322, 514323, 544284, 544286, 546187, 546199, 546201, C07D23980, C07D40114, A61K 31445, A61K 31505

Patent

active

056021380

ABSTRACT:
Compounds of formula I ##STR1## wherein Q.sup.1, m and M have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

REFERENCES:
patent: 5236921 (1993-08-01), Emonds-Alt et al.
A. Graham et al., "Isolation and Characterisation of the Human Lung NK-2 Receptor Gene Using Rapid Amplification of cDNA Ends", Biochemical and Biophysical Research Communications, (1991), vol. 177, No. 1, 8-16.
X. Emonds-Alt et al., "Pharmacological Profile and Chemical Synthesis of SR 48968, a Non-Peptide Antagonist of the Neurokinin A (NK.sub.2) Receptor", Biorganic & Medicinal Chemistry Letters, (1993), vol. 3, No. 5, 925-930.
D. Aharony et al., "Pharmacologic Characterization of the Novel Ligand [4,5--.sup.3 HH-LEU.sup.9 ]Neurokinin-A Binding to NK-2 Receptors on Hamster Urinary Bladder Membranes", (1992), 23, 121-130.
M. Needham et al., "LCR/MEL: A Versatile System for High-Level Expression of Heterologous Proteins in Erythroid Cells", Nucleic Acids Research, (1992), vol. 20, No. 5, 997-1003.

Affiliated with

Also associated with

Rating

NKA affecting piperidyl heterobicyclic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with NKA affecting piperidyl heterobicyclic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and NKA affecting piperidyl heterobicyclic compounds will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-342362