N-heterocycloalkyl carboxamides as serotonergic agents

Details N-heterocycloalkyl carboxamides as serotonergic agents N-heterocycloalkyl carboxamides as serotonergic agents

1994-12-02

1997-02-11

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142358, 514252, 544 586, 544121, 544357, A61K 31535, A61K 3154, C07D41304, C07D41702

Patent

active

056021283

ABSTRACT:
The compounds ##STR1## where R and R.sup.6 are members independently selected from the group consisting of H, CN, OR.sup.2, NO.sub.2, NR.sup.2 R.sup.3, NR.sup.2 COR.sup.3, NR.sup.2 COOR.sup.3, COR.sup.2, COOR.sup.2, CONR.sup.2 R.sup.3, SR.sup.2, SOR.sup.2, SO.sub.2 R.sup.2, SO.sub.2 NR.sup.2 R.sup.3, alkyl, alkenyl, alkynyl, perhaloalkyl, and a halogen; in which R.sup.2 and R.sup.3 are alkyl, alkenyl, alkynyl, phenyl, or benzyl; R.sup.4 is a member selected from the group consisting of H, alkyl, heteroalkyl, in which the hetero atom is oxygen, sulfur or nitrogen, alkenyl and alkynyl; R.sup.5 is ##STR2## where X is O, S or NR.sup.7 and R.sup.7 is H or alkyl and n is 1, 2, 3, 4, 5, or 6; or a pharmaceutically acceptable salt thereof, are useful anxiolytic/antidepressant agents.

REFERENCES:
patent: 3717634 (1973-02-01), Hua et al.
patent: 4182763 (1980-01-01), Casten et al.
patent: 5278160 (1994-01-01), Abou-Gharbia et al.
patent: 5348955 (1994-09-01), Greenlee et al.

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