Spin trapping pharmaceutical compositions and methods for use th

Details Spin trapping pharmaceutical compositions and methods for use th Spin trapping pharmaceutical compositions and methods for use th

1994-03-15

1997-04-22

Burn, Brian M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514 59, 5142262, 514315, 514399, 514400, 514422, 514428, 514517, 514518, 514642, 514645, 514708, 514709, A61K 31255

Patent

active

056229941

ABSTRACT:
Spin trapping compositions in general have now been discovered to be effective in treating a variety of disorders, including disorders such as those arising from ischemia, infection, inflammation, exposure to radiation or cytotoxic compounds, not just of the central and peripheral nervous systems but of peripheral organ disease having a wide variety of etiologies. In the preferred embodiment, the compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, in a suitable pharmaceutical carrier for intravenous, oral, topical, or nasal/pulmonary administration. Many different disorders can be treated using these compounds, including diseases or disorders of the central and peripheral nervous systems, and disorders arising from ischemia, infection, inflammation, oxidation from exposure to radiation or cytotoxic compounds, as well as due to naturally occurring processes such as aging.

REFERENCES:
patent: 5508305 (1996-04-01), Carney
Royston, Anaesthesia 43: 315-320 (1988).
Plummer et al. Anesthesiology 57 :160-166 (1982).
Janzen et al. Free Rad. Res. Comms. 9(3-6)325-35 (1990).
Websters New World Dictionary (3rd Ed.) 1986 p. 17.
Monti et al., "Protective Effects of Spin-Trapping Agents on Adriamycin-Induced Cardiotoxicity in Isolated Rat Atria", Free. Rad. Res. Comms., vol. 14, No. 1, pp. 41-45 (1991).
Jotti et al., "Cardiotoxicity Induced by Doxorubicin in vivo: Protective Activity of the Spin Trap Alpha-phenyl-tert-Butyl Nitrone", Pharmacological Research, vol. 26, No. 2, 1992.
Paracchini et al., "The Spin Trap Alpha-phenyl-tert-butyl Nitrone Protects Against Myelotoxicity and Cardiotoxicity of Adriamycin While Preserving the Cytotoxic Activity", Anticancer Research, vol. 13, pp. 1607-1612 (1993).

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