Treatment of tumors

Details Treatment of tumors Treatment of tumors

1994-03-29

1997-02-11

Burn, Brian M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 514 17, 514 21, A61K 3809

Patent

active

056020945

ABSTRACT:
Malignant gliomas are treated by modifying the eicosanoid biosynthetic pathway with reduction of the inhibitory effect of prostanoids on the cytotoxic activity of NK and LAK cells. Synthetic peptides, corresponding to shared sequences with phospholipase activating protein (PLAP), having the capacity to activate phospholipase A.sub.2 (PLA.sub.2), when administered in a delayed release delivery system, such as with agarose beads induce release of PGE.sub.2, with significant tumor necrosis. A tumor model comprising an air pouch in the dorsum of rats is utilized for effective evaluation of the treatment, with tumor growth, treatment and evaluation of tumors grown therein.

REFERENCES:
patent: 4014909 (1977-03-01), Torossion et al.
patent: 5527775 (1996-06-01), Shorr et al.
Biochem J. (1988)250: 125-32.

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