Process for preparing chiral diol sulfones and dihydroxy...

Details Process for preparing chiral diol sulfones and dihydroxy... Process for preparing chiral diol sulfones and dihydroxy...

2005-04-05

2005-04-05

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C544S297000, C546S080000, C546S089000, C546S093000, C546S173000, C546S342000, C548S502000, C548S537000, C560S119000

Reexamination Certificate

active

06875867

ABSTRACT:
A process is provided for preparing chiral diol sulfones of the structurewhere R3is preferablywhere R4ais preferably aryl such as phenyl, and R1ais preferably alkyl such as t-butyl, which are intermediates used in preparing HMG CoA reductase inhibitors.

REFERENCES:
patent: 6620821 (2003-09-01), Robl
Patel, D.V. et al, Journal of Organic Chemistry 57(26), 1992, pp. 7143-7151.*
U.S. Appl. No. 60/211,594.*
Blakemore, Paul R., et al., Synlett Letters, p. 26-28, 1997.
Smith, Amos B., et al. , J. Org. Chem. 2000, 65, 3738-3753, 1999.
Blakemore, Paul R., et al, J. Chem. Soc., Perkin Trans. 1, 1999, 955-968.
Bellingham, Richard, et al. Synthesis, Feb. 1996, p. 285-296.
Blakemore, Paul R. et. al. Synthesis 1999, No. 7, 1209-1215.

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