Sugar base surfactant for nanocrystals

Details Sugar base surfactant for nanocrystals Sugar base surfactant for nanocrystals

1995-05-19

1997-04-22

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 129, 424490, 424493, 424499, 424 945, A01N 4304, A61K 3170

Patent

active

056229380

ABSTRACT:
Dispersible particles consisting essentially of a crystalline drug substance having a surface modifier having the formula: ##STR1## wherein R is phenyl-(CH.sub.2).sub.10 CO or C.sub.12 H.sub.25 NHCO adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm, methods for the preparation of such particles and dispersions containing the particles. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals.

REFERENCES:
patent: 4107288 (1978-08-01), Oppenheim et al.
patent: 4540602 (1985-09-01), Motoyama et al.
patent: 5118528 (1992-06-01), Fessi et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5403922 (1995-04-01), Garelli-Calvet et al.
Lachman, et al., The Theory and Practice of Industrial Pharmacy, Chapter 2, "Milling", p. 45, (1986).

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