Human glandular kallikrein enhancer, vectors comprising the...

Details Human glandular kallikrein enhancer, vectors comprising the... Human glandular kallikrein enhancer, vectors comprising the...

2005-07-12

2005-07-12

Nguyen, Dave T. (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100

Reexamination Certificate

active

06916918

ABSTRACT:
Enhancers which preferentially increase the transcription of cis-linked coding sequences in prostate cells are provided. Methods of using DNA constructs comprising the enhancers to control transcription of heterologous polynucleotides are also provided. Delivery vehicles comprising the enhancers and methods of using the vehicles are also provided. Adenovirus vectors in which one or more genes are under transcriptional control of the enhancers of the invention are also provided. Further provided are methods of using the adenovirus vectors of the invention to confer selective cytotoxicity in mammalian cells.

REFERENCES:
patent: 4353888 (1982-10-01), Sefton
patent: 4391909 (1983-07-01), Lim
patent: 4603112 (1986-07-01), Paoletti et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4754065 (1988-06-01), Levenson et al.
patent: 4769330 (1988-09-01), Paoletti et al.
patent: 4777127 (1988-10-01), Suni et al.
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4883666 (1989-11-01), Sabel et al.
patent: 4892538 (1990-01-01), Aebischer et al.
patent: 5017487 (1991-05-01), Stunnenberg et al.
patent: 5106627 (1992-04-01), Aesbischer et al.
patent: 5166057 (1992-11-01), Palese et al.
patent: 5219740 (1993-06-01), Miller et al.
patent: 5288641 (1994-02-01), Roizman
patent: 5328470 (1994-07-01), Nabel et al.
patent: 5354674 (1994-10-01), Hodgson
patent: 5501662 (1996-03-01), Hofmann
patent: 5635383 (1997-06-01), Wu et al.
patent: 5648478 (1997-07-01), Henderson
patent: 5656465 (1997-08-01), Panicali et al.
patent: 5658785 (1997-08-01), Johnson
patent: 5679559 (1997-10-01), Kim et al.
patent: 5692622 (1997-12-01), Hergeth
patent: 5705385 (1998-01-01), Bally et al.
patent: 6197293 (2001-03-01), Henderson et al.
patent: 6436394 (2002-08-01), Henderson et al.
patent: 6495130 (2002-12-01), Henderson et al.
patent: 6585968 (2003-07-01), Little et al.
patent: 6676935 (2004-01-01), Henderson et al.
patent: 2003/0068307 (2003-04-01), Yu et al.
patent: 2003/0118555 (2003-06-01), Henderson et al.
patent: 2003/0152553 (2003-08-01), Little et al.
patent: 0 345 242 (1989-12-01), None
patent: 0 345 242 (1989-12-01), None
patent: 0 415 731 (1991-03-01), None
patent: 0 415 731 (1991-03-01), None
patent: 0 440 219 (1991-08-01), None
patent: 2200651 (1988-08-01), None
patent: WO 89/01973 (1989-03-01), None
patent: WO 89/01973 (1989-03-01), None
patent: WO 90/07936 (1990-07-01), None
patent: WO 91/02805 (1991-03-01), None
patent: WO 91/14696 (1991-10-01), None
patent: WO 91/16024 (1991-10-01), None
patent: WO 91/17424 (1991-11-01), None
patent: WO 91/17761 (1991-11-01), None
patent: WO 92/05250 (1992-04-01), None
patent: WO 92/05266 (1992-04-01), None
patent: WO 92/06180 (1992-04-01), None
patent: WO 92/06693 (1992-04-01), None
patent: WO 92/13570 (1992-08-01), None
patent: WO 93/10218 (1993-05-01), None
patent: WO 93/11230 (1993-06-01), None
patent: WO 93/25234 (1993-12-01), None
patent: WO 93/25698 (1993-12-01), None
patent: WO 94/03622 (1994-02-01), None
patent: WO 94/20608 (1994-09-01), None
patent: WO 95/19434 (1995-05-01), None
patent: WO 95/26412 (1995-10-01), None
patent: WO 95/28494 (1995-10-01), None
patent: WO 96/00295 (1996-01-01), None
patent: WO 96/21036 (1996-07-01), None
patent: WO 96/21036 (1996-07-01), None
patent: WO 96/26745 (1996-09-01), None
patent: WO 96/40829 (1996-12-01), None
patent: WO 97/01358 (1997-01-01), None
patent: WO 97/20463 (1997-06-01), None
patent: WO 97/40163 (1997-10-01), None
patent: WO 97/42975 (1997-11-01), None
patent: WO 98/05797 (1998-02-01), None
patent: WO 98/35028 (1998-08-01), None
patent: WO 98/39464 (1998-09-01), None
Trujillo et al (PNAS 88: 3797-3801, 1991).
Wotton et al (J. Biol. Chem. 270(13): 7515-7522, 1995).
Charron et al (J. Biol. Chem. 270(51): 30604-30610, 1995).
Igrahachi et al (J. Biol. Chem. 271(16): 9666-9674, 1996).
Schedlich et al (DNA 6(5): 429-437, (1987)).
Adair et al., “Targeted homologous recombination at the endogenous adenine phosphoribosyltransferase locus in Chinese hamster cells”Proc. Natl. Acad. Sci. USA86:4574-4578 (1989).
Aebischer et al., “Macroencapsulation of dopamine-secreting cells by coextrusion with an organic polymer solution”Biomaterials12:50-56 (1991).
Aebischer et al., “Transplantation of polymer encapsulated neurotransmitter secreting cells: Effect of the encapsulation technique”J. Biomech. Eng. 113:178-183 (1991).
Angermann et al., “Cloning and expression of human salivary-gland kallikrein inEscherichia coli.” Biochem J. 262:787-793, abstract only (Sep. 1989).
Arnberg et al., “Fiber genes of adenoviruses with tropism for the eye and the genital tract”Virol. 227:239-244 (1997).
Ausubel, F.M., et al., eds.Current Protocols in Molecular Biology, Supplement 30, section 7.7.18, Table 7.7.1 (1987).
Ausubel, F.M. et al., eds.Current Protocols in Molecular Biology, Greene Publishing Associates (1989) Title Page and Table of Contents Only.
Bailey et al., “Cell type specific regulation of expression from the Ad40 E1B promoter in recombinant Ad5/Ad40 viruses”,Virology202:695-706 (1994).
Bailey et al., “Enteric adenovirus type 40: Expression of E1B proteins in vivo and in vivo”Virology193:631-641 (1993).
Barba et al., “Thymidine kinase-mediated killing of rat brain tumors”J. Neurosurg79:729-735 (1993).
Beato, “Gene Regulation by steriod hormones”Cell56:335-344 (1989).
Behr et al., “Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA”Proc. Natl. Acad. Sci USA86:6982-6986 (1989).
Behringer et al., “Dwarf mice produced by genetic ablation of growth hormone-expressing cells”Genes Dev. 2:453-461 (1988).
Berkner and Sharp, “Generation of adenovirus by transfection of plasmids”Nucl. Acids Res. 11(17):6003-6020 (1983).
Berkner, “Development of adenovirus vectors for the expression of heterologous genes”BioTechniques6(7):616-618, 620-624, 626, 628, 629 (1988).
Bett et al., “An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3”Proc. Natl. Acad. Sci USA91:8802-8806 (1994).
Bett et al., “Packaging capacity and stability of human adenovirus type 5 vectors”J. Virology67(10):5911-5921 (1993).
Boulikas “Gene therapy of prostate cancer:p53, suicical genes, and other targets”Anticancer Res. 17:1471-1505 (1997).
Braun et al. “Immunogenic duplex nucleic acids are nuclease resistant”J. Immunol. 141(6):2084-1089 (1988).
Bridge et al., “Redundant control of adenovirus late gene expression by early region 4”J. Virol. 63(2):631-638 (1989).
Broach et al. “Vectors for high-level, inducible expression of cloned genes in yeast”Experimental Manipulation of Gene Expression, M. Inouye , ed., Academic Press, pp. 83-117 (1983).
Capecchi, “Altering the genome by homologous recombination”Science244:1288-1292 (1989).
Carson-Jurica et al., “Steroid receptor family: Structure and functions”Endocr. Rev. 11(2):201-220 (1990).
Chander and Schreier, “Artificial viral envelopes containing recombinant human immunodeficiency virus (HIV)gp160”Life Sci. 50(97):481-489 (1992).
Charlesworth et al., “Detection of a prostate-specific protein, human glandular kallikrein (hK2), in sera of patients with elevated prostate-specific antigen levels”Urology49(3):487-493 (1997).
Chaturvedi et al., “Stabilization of triple-stranded oligonucleotide complexes: use of probes containing alternating phosphodiester and stereo-uniform cationic phosphoramidate linkages”Nucleic Acids Res. 24(12):2318-2323 (1996).
Chaudhary et al., “A recombinant single-chain immunotoxin composed of anti-tac variable regions and a truncated diphtheria toxin”Proc. Natl. Acad. Sci. USA87:9491-9494 (1990).
Chen et al., “Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene tra

Affiliated with

Also associated with

Rating

Human glandular kallikrein enhancer, vectors comprising the... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Human glandular kallikrein enhancer, vectors comprising the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human glandular kallikrein enhancer, vectors comprising the... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3412112