Process for preparing albumin protein conjugated...

Details Process for preparing albumin protein conjugated... Process for preparing albumin protein conjugated...

2005-07-05

2005-07-05

Horlick, Kenneth R. (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C436S094000, C536S023100, C536S024300

Reexamination Certificate

active

06913890

ABSTRACT:
A technique for forming conjugates of proteins and oligonucleotides is disclosed in which conjugation is performed while the oligonucleotide is attached to support media such as glass beads. The conjugated product may then be readily removed from the support media. Also disclosed are the conjugated products formed by this technique. The present invention is particularly directed to conjugates of albumin proteins and specifically to bovine serum albumin (BSA).

REFERENCES:
patent: 5939383 (1999-08-01), Remacle et al.
patent: 2002/0051788 (2002-05-01), Pozsgay
patent: 2002/0068818 (2002-06-01), Pozsgay
patent: 2002/0146504 (2002-10-01), Schwartz
patent: 2004/0038331 (2004-02-01), Reddy et al.
Bidaine et al., The phototrityl group photocrosslinking of oligonucleotides to BSA. Bioorganic & Medicinal Chemistry Letters, 6, 1167-1170, 1996.
Bonfils et al, “Drug Targeting: Synthesis and Endocytosis of . . . ”, Nucleic Acids Research, vol. 20, No. 17, 1992, pp 4621-4629.

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