Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-04-26
2005-04-26
McKelvey, Terry (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S029000
Reexamination Certificate
active
06884581
ABSTRACT:
Fra-1 serves as a target for diagnosing and treating glioblastoma multiforme and related brain cancers. Cancer in a brain tissue sample is detected by analyzing expression of Fra-1 in the sample. Brain cancer is treated by modulating Fra-1 gene expression in cells of the cancer, and by inhibiting angiogenesis associated with the cancer by interfering with Fra-1 binding to a VEGF-D promoter.
REFERENCES:
patent: 6124133 (2000-09-01), Taylor et al.
Bhattacharya et al., “Regualtion of the Urokinase-type Plasminogen Activator Receptor Gene in Different Grades of Human Glioma Cell Lines,” Clinical Cancer Research, 7:267-276, 2001.
Won et al., “Stimulation of astrocyte-enriched culture with arachidonic acid increases proenkephalin mRNA: involvement of proto-oncoprotein and mitogen activated protein kinases,” Molecular Brain Research, 76: 396-406, 2000.
Kustikova et al., “Fra-1 Induces Morphological Transformation and Increases In Vitro Invasiveness and Motility of Epitheliod Adenocarcinoma Cells,” Molecular and Cellular Biology, 18: 7095-7105, 1998.
Chiappetta et al., “FRA-1 Expression in Hyperplastic and Neoplastic Thyroid Diseases1,” Clinical Cancer Research, 6: 4300-4307, 2000.
Debinski et al., “VEGF-D is an X-linked/AP-1 Regulated Putative Onco-angiogen in Human Glioblastoma Multiforme,” Molecular Medicine 7: 598-608, 2001.
Debinski Waldemar
Gibo Denise M.
Akerman & Senterfitt
McKelvey Terry
The Penn State Research Foundation
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