Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-07
1998-01-27
Chan, Christina Y.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436 66, G01N 3353, G01N 3372
Patent
active
057121010
ABSTRACT:
The circulating advanced glycosylation endproducts Hb-AGE, serum AGE-peptides and urinary AGE-peptides are disclosed as long term markers of diseases and dysfunctions having as a characteristic the presence of a measurable difference in AGE concentration. Diagnostic and therapeutic protocols taking advantage of the characteristics of these AGEs are disclosed. Antibodies which recognize and bind to in vivo-derived advanced glycosylation endproducts are also disclosed. Methods of using these antibodies as well as pharmaceutical compositions are also disclosed, along with numerous diagnostic applications, including methods for the measurement of the presence and amount of advanced glycosylation endproducts in both plants and animals, including humans, as well as in cultivated and systhesized protein material for therapeutic use.
REFERENCES:
patent: 3654090 (1972-04-01), Hermanns et al.
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4807973 (1989-02-01), Goers et al.
patent: 5223392 (1993-06-01), Cohen
Koenig et al. (1980) Annv. Rev. Med. vol. 31:29-34.
Cerami et al. (1985) Prog. Clin. Biol. Res. vol. 195:79-90.
Torcia et al. (1991) J. Biol. Chem. Suppl. O (15 Part F) p. 248, Abstract (F 408.
Araki et al. J. Biol. Chem. 267:10211-4 (1992).
Horiuchi, S., et al. J. Bio. Chem. 226 (12):7329-7332 (1991).
Nakayama, H., et al. Biochem. Biophys. Res. Com. 162:740-745 (1989).
Suarez, G., et al. J. Bio. Chem. 264 (7):3674-3679 (1989).
Makita et al. J. Bio. Chem. 267 (8):5133-8 (1992).
Gaulton et al. Ann. Rev. Immunol. 4:253-80 (1986).
Radoff et al. Diabetes 39:1510-8 (1990).
Brownlee et al. Annals In. Med. 101:527-37 (1984).
Cohen J. I. Methods 117:121-9 (1989).
Kennedy et al. Diabetologia 26:93-98 (1984).
Vlassara et al., "Function of macrophage receptor for nonenzymatically glycosylated proteins is modulated by insulin levels", Diabetes, 35 Supp. 1, pp. 13a (1986).
Vlassara et al., "Accumulation of diabetic rat peripheral nerve myeline by macrophages increases with the presence of advanced glycosylation endproducts", A. J. Exp. Med 160, pp. 197-207 (1984).
Vlassara et al., "Recognition and uptake of human diabetic peripheral nerve myelin by macrophages", Diabetes, 34 No. 6, pp. 553-557 (1985).
Vlassara et al., "High-affinity-receptor-mediated uptake and degradation of glucose-modified proteins: a potential mechanism for the removal of senscent macromolecules", Proc. Natl. Acad. Sci. U.S.A., 82, pp. 5588-5592 (Sep. 1985).
Vlassara et al., "Novel macrophage receptor for glucose-modified proteins is distinct from previoiusly described scavenger receptors", J. Exp. Med. 164, pp. 1301-9 (1986).
Cerami et al., "Role of nonenzymatic glycosylation in atherogenesis", Journal of Cellular Biochemistry, 30, pp. 111-120 (1986).
Radoff, S. et al., "Characterization of a solubilized cell surface binding protein on macrophages specific for proteins modified nonenzymatically by advanced glycosylation end products", Arch. Biochem. Biophys. 263 No. 2, pp. 418-423 (1988).
Yang, Z. et al., "Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins", J. Exp. Med. 174, pp. 515-524 (1991).
Skolnik, E. et al., "Human and rat mesangial cell receptors for glucose-modified proteins: potential role in kidney tissue remodelling and diabetic nephropathy", J. Exp. Med., 174, pp. 931-939.
Makita, Z. et al., "Hemoglobin-age: a circulating marker of advanced glycosylation", Science 258, pp. 651-653.
Horiuchi, S. et al., "Purification of a receptor for formaldehyde-treated serum albumin from rat liver", J. Biol. Chem., 4,260, pp. 482-488 (1985).
Takata, K. et al., "Scavenger receptor-mediated recognition of maleylated albumin and its relation to subsequent endocytic degradation", Biochem. Biophys. Acta., 984, pp. 273-280 (1989).
Goldstein, J.L. et al., "Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition." Proc. Nat'l Acad. U.S.A. 76, pp. 333-337 (1979).
Kirstein, M. et al., "Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: role in vascular disease of diabetes and aging", Proc. Nat'l. Acad. Sci. U.S.A., 87, pp. 9010-4 (1990).
Fluckiger, R. et al., "Measurement of nonenzymatic protein glycosylation", Methods Enzymol., 106, pp. 77-87 (1984).
Bucala, R. et al., "Characterization of Antisera to the Addition Product Formed by the Nonenzymatic Reaction of 16 3Hydrozyestrone with Albumin", Mol. Immunol., 20, pp. 1289-1292 (1983).
Robard, D. "Statistical Quality Control and Routine Data Processing for Radioimmunoassays and Immunoradiometric Assays", Clin. Chem. 20, pp. 1255-1270 (1974).
McPherson et al., "Role of Fructose in Glycatioinand Cross-Linking of Proteins", Biochemistry, 27, pp. 1901-1907 (1988).
Radoff, S. et al., "Isolation of a Surface Binding Protein Specific for Advanced Glycosylation Endproducts from the Murine Macrophage-Derived Cell Line Raw 264.7", Diabetes, 39, pp. 1510-1518 (1990).
Mitchel, F. et al., "Darstellung Aliphatischer Amadori-Produkte", Chem. Ber., 92, pp. 2836-2840 (1959).
Bradford, M., "A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding", Anal. Biochem., 72, pp. 248-252 (1976).
Edward, C. et al., "Modified Assay for Determination of Hydroxyproline in a Tissue Hydrolyzate", Clin. Clim. Acta., 104, pp. 161-167 (1980).
Cech Emma
Chan Christina Y.
The Rockefeller University
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