Methods and devices for manipulation of magnetically collected m

Details Methods and devices for manipulation of magnetically collected m Methods and devices for manipulation of magnetically collected m

Filed on

1995-06-07

Date issued

1997-04-22

Examiner

Knode, Marian C.

Patent Class

Chemistry: molecular biology and microbiology

SubClass

Measuring or testing process involving enzymes or...

SubSubClass

Involving antigen-antibody binding, specific binding protein...

Other Related Categories

435 5, 435 6, 435 732, 435 794, 436526, 436 52, 436806, 436807, 436824, 422 50, 210222, 210695, G01N 33567, G01N 33553

Type

Patent

Status

active

Patent number

056228317

Description

ABSTRACT:
Methods and devices are disclosed which are useful for collecting magnetic materials in either internally or externally generated magnetic gradient fields, followed by resuspension into solution with a simple manipulation of the magnetic device. The methods provide for removal of excess reagent, washing of magnetic material, and resuspension for analysis, among other uses. The methods are applicable to all types of biological material that are susceptible to magnetic labelling, including, for example, cells, viruses, proteins, hormones, and receptor-ligand complexes. Several devices are disclosed to take advantage of the method for cellular and immunoassay applications, including both internal and external devices. Both flow-through and static separators are disclosed.

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