Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-05-03
2005-05-03
Nguyen, Dave Trong (Department: 1632)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S486000, C424S468000, C424S482000, C424S093200, C435S320100, C435S455000
Reexamination Certificate
active
06887857
ABSTRACT:
The present invention is directed to the use of microparticles to protect the pharmaceutical effectiveness of a pharmaceutically active agent. According to one embodiment, a pharmaceutically acceptable suspension is provided that comprises microparticles and a pharmaceutically active agent. This pharmaceutically acceptable suspension is then exposed to a component or condition that is incompatible with the pharmaceutically active agent, such that the microparticles provide a pharmaceutical effectiveness that is greater than it would have been in the absence of the microparticles. Preferably, the microparticles result in a pharmaceutical effectiveness of the pharmaceutically active agent that is at least 10% greater than the pharmaceutical effectiveness of the pharmaceutically active agent would have been in the absence of the micro particles. Polymer microparticles, such as polystyrene microparticles, are one preferred class of microparticles. The microparticles preferably range from 0.01 to 100 microns in largest dimension, more preferably 0.1 to 10 microns in largest dimension. The microparticles are preferably provided in an amount of 0.1 to 1 wt % within the suspension. Agents comprising polynucleotides, including cells, plasmids and viral vectors, are a preferred class of pharmaceutically active agent. Other embodiments on the invention are directed to pharmaceutically acceptable suspensions, medical devices for parenteral injection, and methods of treatment.
REFERENCES:
patent: 4795642 (1989-01-01), Cohen
patent: 4838877 (1989-06-01), Massau
patent: 5607401 (1997-03-01), Humphrey
patent: 5637399 (1997-06-01), Yoshikawa et al.
patent: 5671754 (1997-09-01), Schmukler et al.
patent: 5824049 (1998-10-01), Ragheb et al.
patent: 5873904 (1999-02-01), Ragheb et al.
patent: 6004943 (1999-12-01), Shi et al.
patent: 6099561 (2000-08-01), Alt
patent: 6248720 (2001-06-01), Mathiowitz
patent: 6368586 (2002-04-01), Jacob
patent: 6369039 (2002-04-01), Palasis et al.
patent: 6372722 (2002-04-01), Bennett
patent: 6398808 (2002-06-01), Palasis
patent: 6500448 (2002-12-01), Johnson
patent: 6638259 (2003-10-01), Palasis et al.
patent: 6663606 (2003-12-01), Barry et al.
patent: 20020032414 (2002-03-01), Ragheb et al.
patent: 20020055721 (2002-05-01), Palasis et al.
patent: 20020098237 (2002-07-01), Donovan et al.
patent: 20020107330 (2002-08-01), Pinchuk et al.
patent: 20030073972 (2003-04-01), Rosenman et al.
patent: 0 465 081 (1992-01-01), None
patent: WO 9406472 (1994-03-01), None
patent: WO 9833487 (1998-08-01), None
patent: WO 9922655 (1999-05-01), None
patent: WO 0130403 (2001-05-01), None
“Standard Specification for Chemical Passivation Treatments for Stainless Steel Parts,” American Society For Testing and Materials, Designation A 967-96, pp. 1-6.
Marshall, Deborah J., et al., “Biocompatibility of Cardiovascular Gene Delivery Catheters with Adenovirus Vectors: An Important Determinant of the Efficiency of Cardiovascular Gene Transfer,” Molecular Therapy, vol. 1, No. 5, May 2000, Part 1 of 2 Parts, p. 423-429.
Post, Mark J. et al., “Adenovirus-Mediated Gene Therapy Through Intramyocardial Injections: Percutaneous Intramyocardial Versus Surgical Epicardial Delivery,” Cardiac and Vascular Regeneration, Jun. 2000, vol. 1, No. 2, pp. 106-113.
Polybead Microspheres, Polysciences, Inc. Microspheres Catalog, 1998-2000, p. 8.
Naimark Wendy
Palasis Maria
Bonham, Esq. David B.
Mayer Fortkort & Williams PC
Nguyen Dave Trong
Sci-Med Life Systems, Inc.
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