Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-07-05
2005-07-05
McKenzie, Thomas C. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S281000
Reexamination Certificate
active
06914065
ABSTRACT:
A class of 3-phenylimidazo[1,2-c]pyrimidine derivatives, of the formula I:(wherein R1, X, Y, and Z are defined herein) are selective ligands for GABA-A receptors and are useful in the treatment or prevention of adverse conditions of the central nervous system, including anxiety and convulsions.
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Tully W. R. et al: “General Approach Leading to the Development of Imidazoquinoline Andimidazopyrimidine Benzodiazepine Receptor Ligands” Drug Development Research, vol. 22, 1991, p. 299-308.
Krogsgaard-Larsent et al: Gaba Receptor Agonists, Partial Agonists, and Antagonists. Design and Therapeutic Prospects: Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 37, No. 16, Ausut 5, 1994, p. 2489-2505.
Hallett David James
Russell Michael Geoffrey Neil
Street Leslie Joseph
McKenzie Thomas C.
Merck Sharp & Dohme Ltd.
Thies J. Eric
Winokur Melvin
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