Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1975-06-04
1978-07-18
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
542416, 542417, 542418, 542424, 544 16, 544 21, A61K 31545, C07D50120
Patent
active
041016580
ABSTRACT:
Antibacterial cephalosporins of the following formula: ##STR1## WHEREIN A and B each is a hydrogen or an amino protecting group; X is a hydroxy or a carboxy protecting group; Y is a hydrogen, halogen, alkyl, alkoxy, or an alkylthio; R is a hydrogen or an alkyl; Z is a group of the formula ##STR2## (in which R.sup.1 and R.sup.2 are the same or different and are a hydrogen, optionally substituted hydrocarbon group, organic acyl, or a group of the formula ##STR3## respectively, in which M and M' are the same or different and are an oxygen or sulfur; R.sup.3 is a hydrocarbon group; R.sup.1 and R.sup.2 can be combined together directly or through a hetero atom); m is 0 or 1; and the broken line shows the presence of a double bond at position 2 or 3, preparable from the compounds shown by the above formula in which Z is an oxygen by treatment with a compound shown by the formula H.sub.2 Z; and pharmaceuticals containing these compounds.
REFERENCES:
patent: 3351596 (1967-11-01), Chamberlin
patent: 3769277 (1973-10-01), Long et al.
patent: 3799922 (1974-03-01), Jen et al.
patent: 3987039 (1976-10-01), Yoshioka et al.
patent: 3997528 (1976-12-01), Yoshioka et al.
Ishikura Koji
Miyazaki Sadao
Murakami Masayuki
Sendo Yuji
Yoshioka Mitsuru
Rizzo Nicholas S.
Shionogi & Co. Ltd.
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