Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-05-03
2005-05-03
Weber, Jon (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S012200, C530S300000
Reexamination Certificate
active
06887846
ABSTRACT:
α-MSH and other amino acid sequences derived from α-MSH were determined to have antimicrobial influences, including against two major and representative cutaneous and mucosal pathogens;Staphylococcus aureusandCandida albicans, Pharmaceutical compositions useful as antimicrobial agents, including for use in reducing the viability of microbes, reducing the germination of yeasts, killing microbes without reducing the killing of microbes by human neutrophils, for treating inflammation in which there is microbial infection without reducing microbial killing, and for increasing the accumulation of cAMP in microbes are disclosed. The antimicrobial agent is selected from the group consisting of one or more peptides including the amino acid sequence KPV, one or more peptides including the amino acid sequence MEHFRWG, or a biologically functional equivalent of any of the foregoing. The most effective of the peprides were those bearing the C-terminal amino acid sequence of α-MSH. i.e., α-MSH (1-13), (6-13), and (11-13).
REFERENCES:
patent: 5028592 (1991-07-01), Lipton
patent: 5157023 (1992-10-01), Lipton
patent: 5739111 (1998-04-01), Mahe
patent: 6001812 (1999-12-01), Mahe
patent: 20010018507 (2001-08-01), Rathjen et al.
patent: 20030109453 (2003-06-01), Catania et al.
patent: 0972 522 (2000-01-01), None
patent: 2784028 (2000-04-01), None
patent: WO97/10838 (1997-03-01), None
patent: WO99/58101 (1999-11-01), None
patent: PCTUS00/07846 (2000-03-01), None
patent: WO0042856 (2000-07-01), None
Cutuli et al., Antimicrobial effects of alpha-MSH peptides. J. Leukocyte Biol. Feb. 2000, vol. 67, No. 2, pp. 233-239.
Deeter et al. Antipyretic properties of centrally administered fragments in the rabbit. Peptides. 1989, vol. 9, pp. 1285-1288.
Hiltz et al. Alpha-MSH peptides inhibit actue inflammation and contact sensitivity. Peptdies. 1990, vol. 11, No. 5, pp. 979-982.
Huang et al. Role of central melanocortins in endotoxin-induced anorexia. Am. J. Physio (Regulatory, Integrative & Comparative Physiology, 45) 1999 vol. 276, No. 3, pp. R864-R871.
Lipton, et al. Mechanisms of antiinflammatory action of the neuro immunomodulatory peptide alpha-MSH. Annals of the N. Y. Acad. Sci. May 1, 1998 vol. 840 pp. 373-380.
Richards et al. Effect of alpha-MSH 11-13 (Lysine-Proline-Valine) on Fever in the Rabbit. Peptides. vol. 5, pp. 815-817.
Weiss et al. Corticotropin-peptide regulation of intracellular cyclic-AMP production in cortical neurons in primary culture. J. Neurochem. 1985, vol. 45, No. 3, pp. 869-874.
Getting et al. POMC gene-derived peptides activate melanocortin type-3 receptor on murine macrophages, suppress cytokine release, and inhibit neutrophil migration in acute experimental inflammation. J. Immunol. Jun. 15, 1999. vol. 162, No. 12, pp. 7446-7453.
Harris et al. Alha-melanocyte stimulating hormone (alpha-MSH) and melanin concentrating hormone (MCH) stimulate phagocytosis by head kidney leucocytes of rainbow trout (Oncoryhnchus mykiss) in vitro. Fish & Shellfish Immunol. Nov. 1998, vol. 8, pp. 631-638.
U.S. Appl. No. 09/533,341, filed Mar. 23, 2000, Catania Anna P. et al.
U.S. Appl. No. 09/535,066, filed Mar. 23, 2000, Lipton.
U.S. Appl. No. 60/200,287, filed Apr. 28, 2000, Lipton.
U.S. Appl. No. 09/774,282, filed Jan. 29, 2001, Lipton.
Airaghi L., et. al., “Elevated concentrations of plasma α-MSH are associated with reduced disease progression in HIV-infected patients,” J. Lab. Clin. Med. 133(3) 309-315 (1999).
Airaghi L, Lettino M, Manfredi MG, Lipton JM, Catania A. Endogenous cytokine antagonists during myocardial ischemia and thrombolytic therapy. Am. Heart J. 130: 204-211, 1995.
Airaghi L. Garofalo L. Cutuli MG. Delgado R. Carlin A. Demitri MT. Badalamenti S. Graziani G. Lipton JM. Catania A. Plasma concentrations of α-melanocyte-stimulating hormone are elevated in patients on chronic haemodialysis. Nephrology Dialysis Transplantation 15:1212-1216, 2000.
Baker, M., et. al., “The Relationship between Interleukin-6 and Herpes Simplex Virus Type-1: Implications for Behavior and Immunopathology,”Brain Behav. Immun.13(3):201-11 (1999).
Baker, et al., “Principles of Ambulatory Medicine”Williams and Wilkins(1982).
Barcellini, W., et al. “Inhibitory Influences of α-MSH peptides on HIV-1 expression in Monocytic cells” 12thWorld AIDS Conference Geneva Abstract No. 60685, Jun. 28-Jul. 3, 1998.
Barcellini W, La Maestra L, Clerici G, Garofalo L, Brini AT, Lipton JM, Catania A. α-MSH peptides inhibit HIV-1 expression in chronically infected promonocytic U1 cells and in acutely infected monocytes. Journal of Leukocyte Biology 68:693-699, 2000.
Bhattacharya A., et. al., “Effect of Cyclic AMP on RNA and Protein Synthesis inCandida albicans,” Biochem, Biophysics. Res. Commun,.77: 1438-44 (1977).
Bickers, D., Sun-Induced Disorders,Emergency Medicine Clinics of North America, 3(4):659-663, 660 (1985).
Capsoni, F., et. al., “Effect of Corticosteriods on Neutrophil Function: Inhibition of Antibody-dependent Cell-Mediated Cytotoxicity (ADCC),”J. Immunopharmacol. 5,217-30 (1983).
Catledge, J.D., et. al., “Clinically Significant Azole Cross-Resistance inCandidaIsolates from HIV-Positive Patients with Oral Condidosis,”AIDS11:1839-44 (1997).
Catania, A., et al., “α-Melanocyte Stimulating Hormone in the Modulation of Host Reactions,”Endocr. Rev.14, 564-576 (1993).
Catania, A., et. al., “Melanocortin Peptides Inhibit Production of Proinflammatory Cytokines in Blood of HIV-Infected Patients,”Peptides,19(6): 1099-1104 (1998).
Catania, A., et. al., “The Neuropeptide α-MSH in HIV Infection and Other Conditions in Humans”Ann. N.Y. Acad. Sci.840: 848-856 (1998).
Catania, A.; et al., “The Neuropeptide α-MSH has Specific Receptors on Neutrophils and Reduces Chemotaxis in Vitro,”Peptides17, 675-679 (1996).
Catania A, Airaghi L Lipton JM. α-MSH in normal human physiology and disease states. Trends Endocrinol. Metab. 11:304-308, 2000.
Catania A, Delgado R Airaghi L, Cutuli M Garofalo L, Carlin A Demitri MT, Lipton JM. α-MSH in systemic inflammation: central and peripheral actions. Annals of the New York Academy of Sciences, 885:183-187, 1999.
Catania A, Grazia M, Manfredi MG, Airaghi L, Ceriani G, Gandino A Lipton JM. Cytokine antagonists in infectious and inflammatory disorders. Annals of the New York Academy of Sciences 741: 149-161 1994.
Catania A, Lipton JM. α-melanocyte-stimulating hormone peptides in host responses: from basic evidence to human research. Annals of the New York Academy of Sciences 680: 412-423, 1993.
Catania A, Cutli M, Garofalo L, Airaghi L, Valenza F, Lipton JM, Gattinoni L. Plasma concentrations and anti-L-cytokine effects of α-melanocyte stimulating hormone in septic patients. Crit. Care Med. 28: 1403-1407, 2000.
Catania A, Airaghi L, Motta P, Manfredi MG, Annoni G, Pettenati C, Brambilla F and Lipton JM. Cytokine antagonists in aged subjects and their relation with cellular immunity. Journal of Gerontology: Biological Sciences 52A: B93-97, 1997.
Catania A, Manfredi MG, Airaghi L, Vivirito MC, Capetti A, Milazzo F, Lipton JM and Zanussi C. Plasma concentration of cytokine antagonists in patients with HIV infection. Neuroimmunomodulation 1: 42-49, 1994.
Catania A, Airaghi L, Manfredi MG, Vivirito MC, Milazzo F, Lipton JM, Zanussi C: Proopiomelanocortin-derived peptides and cytokines: relations in patients with acquired immunodeficiency syndrome. Clinical Immunology and Immunopathology 66: 73-79, 1993.
Cavello, J. and Deleo, V., Suburn,Dermatologic Clinics,4(2): 181-187, 181 (1986).
Ceriani G., et. al., “Central Neurogenic Antiinflammatory Action of α-MSH: Modulation of Peripheral Inflammation Induced by Cytokines and other Mediators of Inflammation,”Neuroendocrinology,59:138-143 (1994).
Ceriani G, Diaz J, Murphree S, Catania A, Lipton JM. The neuropeptide alpha-melanocyte-stimulating hormone inhibits experimental arthritis in rats. Neur
Catania Anna Pia
Lipton James M.
Perkins Coie LLP
Snedden Sheridan
Weber Jon
Zengen, Inc.
LandOfFree
Antimicrobial amino acid sequences derived from... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antimicrobial amino acid sequences derived from..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antimicrobial amino acid sequences derived from... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3397539