Pharmaceutical compositions comprising cyclic...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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C514S110000, C514S105000

Reexamination Certificate

active

06914056

ABSTRACT:
Cyclic glycerophosphates and analogs thereof (CGs) are shown to exert neutral promoting activities in target cells. Such activities include promotion of neuronal outgrowth, promotion of nerve growth, provision of dopaminotrophic supporting envrionment in a diseased portion of the brain, prevention of nerve degeneration and nerve rescue. These activities of the CGs render them useful for treatment of various disorders including but not limited to mental disorders such as, for example, schizophrenia, dementia or disorders resulting in learning disablities. In addition, these CGs may be used for the treatment of neurodegenerative conditions such as Altzheimer's diesease, Parkinson's disease, conditions resulting from exposure to harmful environmental factors or resulting from a mechanical injury. The CGs may also be used to treat an individual suffering from a primary neurodengenerative condition in order to prevent or reduce the appearance of secondary degeneration in additional nerves (“nerve rescue”).

REFERENCES:
patent: 4472320 (1984-09-01), Ashani et al.
patent: 5565439 (1996-10-01), Piazza et al.
patent: 6150345 (2000-11-01), Chun et al.
patent: WO 00/09139 (2000-02-01), None
patent: WO 00/57864 (2000-10-01), None
Merck Index, Fifteenth edition, 1989, Merck & Co. Inc. pp. 1336-1340, 1532-1539.
Friedman, P. et al; “Conversion of Lysophospholipids to Cyclic Lysophosphatidic Acid by Phospholipase D”Journal of Biological Chemistry; vol. 271, No. 2, 1996; pp. 953-957.
M. Shinitzky et al; “Induction of Intracellular Signaling by Cyclic Glycerophosphates and their Deoxy Analogues”,European Journal of Biochemistry; vol. 267, No. 9, 2000; pp. 2547-2554.
M. Mukai et al; Inhibition of Tumor Invasion and Metastasis by a Novel Lysophosphatidic Acid;Int. J. Cancer; 1999; vol. 81 No. 6; pp. 918-922.
S. Kobayashi et al; “Tumor Metastasis Inhibitors Containing 1-0-acylglycerol-2,3-phosphates”; STN; Database Accession No. 126:220705; and JP 09 025235; 1997; Abstract Only.
S. Kobayashi et al; “Preparation of -0-acrylglycerol-2,3-phosphates and DNA Polymerase.alpha.inhibitors containing them”; Database Accession No. 124:76506; and JP 07 258278; 1995; Abstract Only.
S. Kobayashi et al; “Method for Preparation of 1-0-acylglycerol-2,3-cyclic phosphate”; STN; Database Accession No. 123:144502; and JP 06 228169; 1994; Abstract Only.
S. Kobayashi et al; “Promoters of Protein Phosphokinase C activation Containing 1-0-acylglycerol 2,3-cyclic phosphate”; STN; Database Accession No. 123:350234; and JP 07 149772; 1995; Abstract Only.
D. C. Ayres et al; “The Organic Chemistry of Phosphorus. Part V.”;J. Chem. Soc. 1957; pp. 1109-1114.
M. Revel et al; “Phosphorus Heterocycles. XXVIII. NMR Study of 4-monosubstituted 1,3,2-dioxa- and—dithiaphospholane Derivatives”;Org. Magn. Reson.; vol. 8, No. 8; pp. 399-496, 1976.
T. Ukita et al; “Organic Phosphates. I. Synthesis of 1,2-Diol Cyclic Phosphates”;Pharm. Bull; vol. 5; pp. 121-126; 1957.
B. Su et al; “Identification of a Putative Tumor Marker in Breast and Colon Cancer”;Cancer Res.; vol. 53, No. 8; pp. 1751-1754, 1993.
S. Abbott et al; “Chiral ′160, 170, 180!phosphate monoesters. 1.Assymetric synthesis and stereochemical analysis of ′1(R)-160, 170, 180!phospho-(S)-propane-1,2-diol”J. AM. Chem. Soc.; 1978, vol. 100, No. 8, pp. 2558-2560.
R. K. Boyd et al; “Glycerol 1,2-Cyclic Phosphate in Centric Diatoms”;Journal of Biological Chemistry; vol. 262; No. 26, 199; pp. 12406-12408.
N. Clarke et al; Enzymatic Formation of Glycerol 1:2-Cyclic Phosphate;Biochem J., vol. 153, pp. 745-747; 1976.
R. M. C. Dawson; “Advances in Phosphoglyceride Chemistry”;Ann. Rept. Progr. Chem.vol. 55, pp. 365-377; 1958.
R. M. C. Dawson et al; “The Enzymatic Formation of myoinositol 1:2-Cyclic Phosphate from Phosphatidylinositol”;Biochem J.; vol. 122, pp. 605-607, 1971.
P. Friedman et al; “Conversion of Lysophospholipids to Cyclic Lysophosphatidic Acid by Phospholipase D”;The Journal of Biolgical Chemistry; vol. 271, No. 2, pp. 953-957; 1996.
T. Hagg et al: Ciliary Neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo;Proc. Natl. Acad. Sci. USA; vol. 90, pp. 6315-6319; 1993.
E. P. Kennedy et al; “The Function of Cytidine Coenzymes in the Biosynthesis of Phospholipides”;J. Biol. Chem., vol. 22, pp. 193-214; 1956.
B. Knusel et al; “Selective and Nonselective Stimulation of Central Cholinergic and Dopaminergic Development in vitro by Nerve Growth Factor, Basic Fibroblast Growth Factor, Epidermal Growth Factor, Insulin and the Insulin-like Growth Factors I and II”;The Journal of Neuroscience; vol. 10, No. 2, pp. 558-570, 1990.
B. Knusel et al; “Promotion of Central Cholinergic and Dopaminergic Neuron Differentiation by Brain Derived Neurotrophic factor but not Neurotrophin 3”;Pro. Natl. Acad. Sci.; vol. 88; pp. 961-965, 1991.
L. F. Leloir; “The Enzymatic Transformation of Uridine Diphosphate Glucose into a Galactose Derivative”;Biochem. Biophys. J. vol. 33; pp. 186190; 1951.
L. H. LIn et al; “A Glial Cell Line-Derives Neurotrophic Factor for Midbrain Dopaminergic Neurons”;Science; vol. 260; pp. 1130-1134, 1993.
R. Markham et al; “The Structure of Ribonucleic Acid”;J.D. Biochem J.; vol. 52, pp. 552-557, 1952.
M. Shinitzky et al; “Formation of 1,3-Cyclic Glycerophosphate by the Action of Phospholipase C on Phosphatidylglycerol”;The Journal of Biological Chemistry; vol. 268; pp. 14109-14114, 1993.
N. Kinor et al; “Cyclic Glycerophosphates for the treatment of Parkinson's Disease”;Neurosci. Lett.; vol. 54; S24; 1999.
A. Tomac et al; Protection and Repair of the Nigrostriatal dopaminergic system by GDNF in vivo;Nature; vol. 373, pp. 335-339, 1995.
T. Ukita et al; “Studies on the Alkaline Hydrolysis of Lecithin: Synthesis of Cyclic 1,2-Glycerophosphate”;J. Biol. Chem.; vol. 216, pp. 867-874, 1955.

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