Membrane-bound desaturases

Details Membrane-bound desaturases Membrane-bound desaturases

2005-03-08

2005-03-08

Rao, Manjunath (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

C435S069100, C435S183000, C435S189000, C435S190000, C435S191000, C435S252300, C435S254200, C435S348000, C435S410000, C435S415000, C435S419000, C435S426000, C435S320100, C435S325000, C536S023200, C536S023400, C536S023600

Reexamination Certificate

active

06864077

ABSTRACT:
This invention relates to an isolated nucleic acid fragment encoding a delta-6 desaturase or sphingolipid desaturase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the delta-6 desaturase or sphingolipid desaturase, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the delta-6 desaturase or sphingolipid desaturase in a transformed host cell.

REFERENCES:
patent: 9621022 (1996-07-01), None
patent: 9845461 (1998-10-01), None
Olga Sayanova et al., PNAS, vol. 94:4211-4216, 1997, Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of Delta6-desaturated fatty acids in transgenic tobacco.
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National Center For Biotechnology Information General Identifier No. 4104056. Jan. 29, 1999. E. Delhaize et al., Aluminum tolerance in yeast conferred by over-expression of wheat genes.
National Center For Biotechnology Information General Identifier No. 1040729, Feb. 3, 2001, P. Sperling et al., A cyctochrome-b5-containing fusion protein similar to plant acyl lipid desaturase.
P. Sperling et al., Biochem. Soc. Trans., vol. 28(6):638-641, 2000, Further characterization of Delta8-sphingollpid desaturases from higher plants.
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