Antitumor agents

Details Antitumor agents Antitumor agents

2005-03-15

2005-03-15

Huang, Evelyn Mei (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S157000, C546S153000

Reexamination Certificate

active

06867219

ABSTRACT:
The invention provides compounds of formula I:wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.

REFERENCES:
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Draetta et al. “Section V. Topics in Biology”, Annual Reports in Medicinal Chemistry, 31, 1996, Academic Press, San Diego, pp 241-246.*
Salmon et al., “Principles of Cancer Therapy”, Oncology, XIV, pp 1036-1049, 1999.*
Balasubramanian et al. “recent Developments in Cancer, etc.,” Annual Reports in Medicinal Chemistry, 33, 1998, Academic Press, San Diego, pp 151-159.*
Hazeldine, Stuart T., et al., “J. Med. Chem. 2001, 44”,Design, Synthesis, and Biological Evaluation of Analogues of Design, Synthesis, and Biological Evaluation of Analogues of the Antitumor Agent, 2-(4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy)proplonic Acid(XK469), (2001), p. 1758-1776.
Hazeldine, Stuart T., et al., “J. Med. Chem. 2002, 45”,II, Synthesis and Biological Evaluation of Some Bioisosteres and Congeners of the Antitumor Agent, 2-(4-[97-Chloro-2-quinoxalinyl)oxy]phenoxylproplonic Acid(XK469), (2002), p. 3130-3137.
Corbett, Thomas , et al., “Preclinical Antitumor Efficacy of Analogs of XK469:sodium-(s-{4-(7-chloro-2-quinoxalinyloxy) phenoxy}propionate”,Investigational New Drugs, (1998), 129-139.

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