Process for producing N-acetylneuraminic acid

Details Process for producing N-acetylneuraminic acid Process for producing N-acetylneuraminic acid

2005-01-25

2005-01-25

Rao, Manjunath (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

C435S004000, C435S041000, C435S042000, C435S068100, C435S069100, C435S094000, C435S099000, C435S105000, C435S136000, C435S146000, C435S183000, C435S226000, C435S243000, C435S252300, C435S320100, C435S095000, C435S096000, C435S097000, C435S098000, C435S184000, C435S185000, C435S186000, C435S187000, C435S188000, C435S189000, C435S190000, C435S191000, C435S192000, C435S193000, C435S194000, C435S195000, C435S196000, C435S197000, C435S198000, C435S199000, C435S200000, C435S201000, C435S202000, C435S203000, C435S

Reexamination Certificate

active

06846656

ABSTRACT:
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process comprises: allowing (i) a culture of a microorganism having N-acetylneuraminic acid aldolase activity or N-acetylneuraminic acid synthetase activity, or a treated matter of the culture, (ii) a culture of a microorganism capable of producing pyruvic acid or a treated matter of the culture, or a culture of a microorganism capable of producing phosphoenolpyruvic acid or a treated matter of the culture, (iii) N-acetylmannosamine, and (iv) an energy source which is necessary for the formation of pyruvic acid or phosphoenolpyruvic acid to be present in an aqueous medium to form and accumulate N-acetylneuraminic acid in the aqueous medium; and recovering N-acetylneuraminic acid from the aqueous medium.

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