Compound

Details Compound Compound

2005-07-26

2005-07-26

Solola, Taofiq (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S285000

Reexamination Certificate

active

06921776

ABSTRACT:
A compound is described. In particular, a non-steroidal sulphamate compound is described. The compound is suitable for use as an inhibitor of oestrone sulphatase. The compound is of general Formula (A),wherein R1-R6are independently selected from H, halo, hydroxy, sulphamate, alkyl and substituted variants or salts thereof, but wherein at least one of R1-R6is a sulphamate group; and wherein X is any one of S, NH, a substituted N, CH2, or a substituted C.

REFERENCES:
patent: 4600788 (1986-07-01), Creuzet et al.
patent: 4618622 (1986-10-01), Schlecker et al.
patent: 4829084 (1989-05-01), Bailey
patent: 6011024 (2000-01-01), Reed et al.
patent: 6239169 (2001-05-01), Reed et al.
patent: 0 111 746 (1983-11-01), None
patent: 0 403 185 (1990-06-01), None
patent: 2543140 (1983-03-01), None
patent: WO 92/21353 (1992-12-01), None
patent: WO 93/05064 (1993-03-01), None
patent: WO 97/32872 (1997-09-01), None
Ballabio, A. et al., “Steroid Sulfatase Deficiency and X-Linked Ichthyosis,” Part 18: Hormones, Chapter 166:4241-4262, 2001.
Corral, C. et al., “Synthesis and Anticholinesterase Activity of a Series of Aryl N,N-dimentylsulfamates,”Chemical Abstracts, 62: 7070, 1965.
Hernandez-Martin, A. et al., “X-linked Ichthyosis: an Update,”British J. Derm., 141: 617-627, 1999.
Howarth, N. et al., “Estrone Sulfamates: Potent Inhibitors of Estrone Sulfatase with Therapeutic Potential,”J. Med. Chem., 37:219-221, 1994.
Nelson, K. et al., “Murine Arylsulfatase C: Evidence for Two:Isozymes,”Experientia, 39:740-42, 1983.
Purohit, A. et al., “Inactivation of Steroid Sulfatase by an Active Site-Directed Inhibitor, Estrone-3-O-Sulfamate,”Biochemistry, 34: 11508-11514, 1995.
Reed, M.J. et al., “The Role of Cytokines and Sulphatase Inhibitors in Regulating Oestrogen Synthesis in Breast Tumours,”J. Steroid Biochem. Molec. Biol., 53(1-6):413-420, 1995.
Sahm, U.G. et al., “Development of an Oral Formulation for Oestrone 3-O-Sulphamate, a Potent Sulphatase Inhibitor,”Pharmaceutical Sciences, 2: 17-20, 1996.
Woo, L.W. et al., “Active Site Directed Inhibition of Estrone Sulfatase by Nonsteroidal Coumarin Sulfamates,”J. Med. Chem., 39: 1349-51, 1996.
Woo, L.W. et al., “Heteroatom-Substituted Analogues of the Active-Site Directed Inhibitor Estra-1,3,5(10)-Trien-17-One-3-Sulphamate Inhibit Estrone Sulphatase by a Different Mechanism,”J. Steroid Biochem. Molec. Biol., 57(1/2): 79-88, 1996.

Affiliated with

Also associated with

Rating

Compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3389229